8SL9
Crystal structure of Francisella tularensis HPPK-DHPS in complex with HPPK inhibitor HP-73
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | polymer | 423 | 48427.9 | 1 | UniProt (Q5NGA7) Pfam (PF01288) Pfam (PF00809) | Francisella tularensis subsp. tularensis | |
| 2 | B (A) | 5'-S-[(2R,4R)-1-{2-[(2-amino-7,7-dimethyl-4-oxo-3,4,7,8-tetrahydropteridine-6-carbonyl)amino]ethyl}-2-carboxypiperidin-4-yl]-5'-thioadenosine | non-polymer | 672.7 | 1 | Chemie (H73) | |||
| 3 | C, D, E, F, G... (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 22 | Chemie (EDO) | |||
| 4 | AA, Y, Z (A) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
| 5 | BA (A) | water | water | 18.0 | 371 | Chemie (HOH) |
Sequence modifications
A: 1 - 421 (UniProt: Q5NGA7)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Gly 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 48427.9 | |
| Non-Polymers* | Number of molecules | 26 |
| Total formula weight | 2144.6 | |
| All* | Total formula weight | 50572.5 |
