8SJB
Crystal structure of Zn2+ bound calprotectin variant H87C
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Protein S100-A8 | polymer | 88 | 10141.7 | 2 | UniProt (P05109) Pfam (PF01023) | Homo sapiens (human) | Calgranulin-A,Calprotectin L1L subunit,Cystic fibrosis antigen,CFAG,Leukocyte L1 complex light chain,Migration inhibitory factor-related protein 8,MRP-8,p8,S100 calcium-binding protein A8,Urinary stone protein band A |
| 2 | C, D (C, D) | Protein S100-A9 | polymer | 99 | 11637.1 | 2 | UniProt (P06702) Pfam (PF01023) | Homo sapiens (human) | Calgranulin-B,Calprotectin L1H subunit,Leukocyte L1 complex heavy chain,Migration inhibitory factor-related protein 14,MRP-14,p14,S100 calcium-binding protein A9 |
| 3 | E, F, H, I, L... (A, B, C, D) | CALCIUM ION | non-polymer | 40.1 | 8 | Chemie (CA) | |||
| 4 | G, J (A, B) | NONAETHYLENE GLYCOL | non-polymer | 414.5 | 2 | Chemie (2PE) | |||
| 5 | K (C) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 6 | P, Q, R, S (A, B, C, D) | water | water | 18.0 | 250 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 88 (UniProt: P05109)
C, D: 2 - 100 (UniProt: P06702)
| PDB | External Database | Details |
|---|---|---|
| Asn 17 | His 17 | engineered mutation |
| Asn 27 | His 27 | engineered mutation |
| Ser 42 | Cys 42 | engineered mutation |
| Cys 87 | His 87 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Asn 88 | His 91 | engineered mutation |
| Asn 92 | His 95 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 43557.6 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1215.0 | |
| All* | Total formula weight | 44772.6 |
