8SIQ
Crystal structure of SARS-CoV-2 spike receptor-binding domain in complex with broadly neutralizing antibodies CC25.36 and CV38-142 Fab
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Spike protein S1 | polymer | 205 | 23104.9 | 1 | UniProt (P0DTC2) Pfam (PF09408) | Severe acute respiratory syndrome coronavirus 2 | |
| 2 | B (H) | CC25.36 Fab heavy chain | polymer | 230 | 24429.3 | 1 | Homo sapiens (human) | ||
| 3 | C (L) | CC25.36 Fab light chain | polymer | 217 | 22801.1 | 1 | Homo sapiens (human) | ||
| 4 | D (M) | CV38-142 Fab heavy chain | polymer | 226 | 24068.0 | 1 | Homo sapiens (human) | ||
| 5 | E (N) | CV38-142 Fab light chain | polymer | 217 | 23745.3 | 1 | Homo sapiens (human) | ||
| 6 | F (B) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 732.7 | 1 | In PDB GlyTouCan (G32152BH) |
Sequence modifications
A: 333 - 530 (UniProt: P0DTC2)
| PDB | External Database | Details |
|---|---|---|
| Gly 531 | - | expression tag |
| His 532 | - | expression tag |
| His 533 | - | expression tag |
| His 534 | - | expression tag |
| His 535 | - | expression tag |
| His 536 | - | expression tag |
| His 537 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 118148.5 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 732.7 | |
| All* | Total formula weight | 118881.2 |
