8SI9
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus allopregnanolone
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Gamma-aminobutyric acid receptor subunit beta-2 | polymer | 364 | 41810.1 | 2 | UniProt (P47870) Pfam (PF02931) Pfam (PF02932) | Homo sapiens (human) | GABA(A) receptor subunit beta-2 |
| 2 | B, D (B, D) | Gamma-aminobutyric acid receptor subunit alpha-1 | polymer | 358 | 41061.2 | 2 | UniProt (P14867) Pfam (PF02931) Pfam (PF02932) | Homo sapiens (human) | GABA(A) receptor subunit alpha-1 |
| 3 | E (E) | Gamma-aminobutyric acid receptor subunit gamma-2 | polymer | 417 | 47673.1 | 1 | UniProt (P18507) Pfam (PF02931) Pfam (PF02932) | Homo sapiens (human) | GABA(A) receptor subunit gamma-2 |
| 4 | F, H (I, L) | Kappa Fab Light Chain | polymer | 213 | 23505.9 | 2 | Mus musculus (mouse) | ||
| 5 | G, I (J, K) | IgG2b Fab Heavy Chain | polymer | 454 | 49811.0 | 2 | Mus musculus (mouse) | ||
| 6 | J, L, M (F, H, M) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 3 | In PDB GlyTouCan (G15407YE) | |||
| 7 | K (G) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1721.5 | 1 | In PDB GlyTouCan (G40702WU) | |||
| 8 | N (N) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 9 | O, R (A, C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 10 | P, T (A, C) | allopregnanolone | non-polymer | 318.5 | 2 | Chemie (Y4B) | |||
| 11 | Q, S (B, C) | GAMMA-AMINO-BUTANOIC ACID | non-polymer | 103.1 | 2 | Chemie (ABU) |
Sequence modifications
A, C: 1 - 307 (UniProt: P47870)
A, C: 315 - 341 (UniProt: P47870)
B, D: 1 - 312 (UniProt: P14867)
B, D: 320 - 358 (UniProt: P14867)
E: 1 - 322 (UniProt: P18507)
E: 329 - 357 (UniProt: P18507)
A, C: 315 - 341 (UniProt: P47870)
| PDB | External Database | Details |
|---|---|---|
| Ser 308 | - | linker |
| Gln 309 | - | linker |
| Pro 310 | - | linker |
| Ala 311 | - | linker |
| Arg 312 | - | linker |
| Ala 313 | - | linker |
| Ala 314 | - | linker |
| Val 342 | - | expression tag |
| Asp 343 | - | expression tag |
| Gly 344 | - | expression tag |
| Ser 345 | - | expression tag |
| Gly 346 | - | expression tag |
| Ala 347 | - | expression tag |
| Thr 348 | - | expression tag |
| Asn 349 | - | expression tag |
| Phe 350 | - | expression tag |
| Ser 351 | - | expression tag |
| Leu 352 | - | expression tag |
| Leu 353 | - | expression tag |
| Lys 354 | - | expression tag |
| Gln 355 | - | expression tag |
| Ala 356 | - | expression tag |
| Gly 357 | - | expression tag |
| Asp 358 | - | expression tag |
| Val 359 | - | expression tag |
| Glu 360 | - | expression tag |
| Glu 361 | - | expression tag |
| Asn 362 | - | expression tag |
| Pro 363 | - | expression tag |
| Gly 364 | - | expression tag |
B, D: 320 - 358 (UniProt: P14867)
| PDB | External Database | Details |
|---|---|---|
| Ser 313 | - | linker |
| Gln 314 | - | linker |
| Pro 315 | - | linker |
| Ala 316 | - | linker |
| Arg 317 | - | linker |
| Ala 318 | - | linker |
| Ala 319 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Trp -36 | - | expression tag |
| Ser -35 | - | expression tag |
| His -34 | - | expression tag |
| Pro -33 | - | expression tag |
| Gln -32 | - | expression tag |
| Phe -31 | - | expression tag |
| Glu -30 | - | expression tag |
| Lys -29 | - | expression tag |
| Gly -28 | - | expression tag |
| Gly -27 | - | expression tag |
| Gly -26 | - | expression tag |
| Ser -25 | - | expression tag |
| Gly -24 | - | expression tag |
| Gly -23 | - | expression tag |
| Gly -22 | - | expression tag |
| Ser -21 | - | expression tag |
| Gly -20 | - | expression tag |
| Gly -19 | - | expression tag |
| Ser -18 | - | expression tag |
| Ser -17 | - | expression tag |
| Ala -16 | - | expression tag |
| Trp -15 | - | expression tag |
| Ser -14 | - | expression tag |
| His -13 | - | expression tag |
| Pro -12 | - | expression tag |
| Gln -11 | - | expression tag |
| Phe -10 | - | expression tag |
| Glu -9 | - | expression tag |
| Lys -8 | - | expression tag |
| Leu -7 | - | expression tag |
| Glu -6 | - | expression tag |
| Val -5 | - | expression tag |
| Leu -4 | - | expression tag |
| Phe -3 | - | expression tag |
| Gln -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Pro 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 323 | - | linker |
| Gln 324 | - | linker |
| Pro 325 | - | linker |
| Ala 326 | - | linker |
| Arg 327 | - | linker |
| Ala 328 | - | linker |
| Ser 358 | - | expression tag |
| Arg 359 | - | expression tag |
| Gly 360 | - | expression tag |
| Ser 361 | - | expression tag |
| Gly 362 | - | expression tag |
| Ala 363 | - | expression tag |
| Thr 364 | - | expression tag |
| Asn 365 | - | expression tag |
| Phe 366 | - | expression tag |
| Ser 367 | - | expression tag |
| Leu 368 | - | expression tag |
| Leu 369 | - | expression tag |
| Lys 370 | - | expression tag |
| Gln 371 | - | expression tag |
| Ala 372 | - | expression tag |
| Gly 373 | - | expression tag |
| Asp 374 | - | expression tag |
| Val 375 | - | expression tag |
| Glu 376 | - | expression tag |
| Glu 377 | - | expression tag |
| Asn 378 | - | expression tag |
| Pro 379 | - | expression tag |
| Gly 380 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 9 |
| Total formula weight | 360049.7 | |
| Branched | Number of molecules | 5 |
| Total formula weight | 3905.6 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1285.6 | |
| All* | Total formula weight | 365240.9 |
