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8SI7

Cryo-EM structure of TRPM7 in GDN detergent in complex with inhibitor VER155008 in closed state

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C, D
(A, B, C, D)
Transient receptor potential cation channel subfamily M member 7polymer1279146888.94UniProt (Q923J1)
Pfam (PF18139)
Pfam (PF00520)
Pfam (PF16519)
Mus musculus (house mouse)Channel-kinase 1,Long transient receptor potential channel 7,LTrpC-7,LTrpC7,Transient receptor potential-phospholipase C-interacting kinase,TRP-PLIK
2AB, BB, CA, DA, DB...
(C, B, D, A)
(2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphatenon-polymer760.152Chemie (POV)
3AA, H, IB, QA
(B, A, D, C)
4-[[(2R,3S,4R,5R)-5-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-3,4-dihydroxy-oxolan-2-yl]methoxymethyl]benzonitrilenon-polymer556.44Chemie (3FD)
4BA, I, JB, RA
(B, A, D, C)
CHOLESTEROLnon-polymer386.74Chemie (CLR)
5CB, JA, Q, ZA
(C, B, A)
2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diolnon-polymer516.84Chemie (DU0)
6V
(A)
CALCIUM IONnon-polymer40.11Chemie (CA)
7RB, SB, TB, UB
(A, B, C, D)
waterwater18.0156Chemie (HOH)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight587555.5
Non-Polymers*Number of molecules65
Total formula weight45403.3
All*Total formula weight632958.8
*Water molecules are not included.

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PDB entries from 2025-07-23

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