8SI7
Cryo-EM structure of TRPM7 in GDN detergent in complex with inhibitor VER155008 in closed state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Transient receptor potential cation channel subfamily M member 7 | polymer | 1279 | 146888.9 | 4 | UniProt (Q923J1) Pfam (PF18139) Pfam (PF00520) Pfam (PF16519) | Mus musculus (house mouse) | Channel-kinase 1,Long transient receptor potential channel 7,LTrpC-7,LTrpC7,Transient receptor potential-phospholipase C-interacting kinase,TRP-PLIK |
| 2 | AB, BB, CA, DA, DB... (C, B, D, A) | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate | non-polymer | 760.1 | 52 | Chemie (POV) | |||
| 3 | AA, H, IB, QA (B, A, D, C) | 4-[[(2R,3S,4R,5R)-5-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-3,4-dihydroxy-oxolan-2-yl]methoxymethyl]benzonitrile | non-polymer | 556.4 | 4 | Chemie (3FD) | |||
| 4 | BA, I, JB, RA (B, A, D, C) | CHOLESTEROL | non-polymer | 386.7 | 4 | Chemie (CLR) | |||
| 5 | CB, JA, Q, ZA (C, B, A) | 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol | non-polymer | 516.8 | 4 | Chemie (DU0) | |||
| 6 | V (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 7 | RB, SB, TB, UB (A, B, C, D) | water | water | 18.0 | 156 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 587555.5 | |
| Non-Polymers* | Number of molecules | 65 |
| Total formula weight | 45403.3 | |
| All* | Total formula weight | 632958.8 |
