8SI2

Cryo-EM structure of TRPM7 in MSP2N2 nanodisc in apo state

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Transient receptor potential cation channel subfamily M member 7	polymer	1279	146888.9	4	UniProt (Q923J1) Pfam (PF18139) Pfam (PF00520) Pfam (PF16519) In PDB	Mus musculus (house mouse)	Channel-kinase 1,Long transient receptor potential channel 7,LTrpC-7,LTrpC7,Transient receptor potential-phospholipase C-interacting kinase,TRP-PLIK
2	B, C, A, D	(2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate	non-polymer		760.1	64	Chemie (POV)
3	B, A, D, C	CHOLESTEROL	non-polymer		386.7	4	Chemie (CLR)
4	C, B, A, D	2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol	non-polymer		516.8	4	Chemie (DU0)
5	A	SODIUM ION	non-polymer		23.0	2	Chemie (NA)
6		water	water		18.0	168	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	587555.5
Non-Polymers*	Number of molecules	74
	Total formula weight	52304.5
All*	Total formula weight	639860.0

*Water molecules are not included.