8SES

Cryo-EM Structure of RyR1 + Adenine

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Ryanodine receptor 1	polymer	5037	565908.6	4	UniProt (P11716) Pfam (PF08709) Pfam (PF01365) Pfam (PF02026) Pfam (PF08454) Pfam (PF06459) Pfam (PF00520) Pfam (PF02815) Pfam (PF00622) Pfam (PF21119)	Oryctolagus cuniculus (rabbit)	RYR-1,RyR1,Skeletal muscle calcium release channel,Skeletal muscle ryanodine receptor,Skeletal muscle-type ryanodine receptor,Type 1 ryanodine receptor
2	E, F, G, H (E, F, G, H)	Glutathione S-transferase class-mu 26 kDa isozyme,Peptidyl-prolyl cis-trans isomerase FKBP1B	polymer	350	40045.0	4	UniProt (P08515) UniProt (P68106) Pfam (PF02798) Pfam (PF14497) Pfam (PF00254)	Homo sapiens (human)	GST 26,Sj26 antigen,SjGST,PPIase FKBP1B,12.6 kDa FK506-binding protein,12.6 kDa FKBP,FKBP-12.6,FK506-binding protein 1B,FKBP-1B,Immunophilin FKBP12.6,Rotamase,h-FKBP-12
3	I, K, M, O (A, B, C, D)	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
4	J, L, N, P (A, B, C, D)	ADENINE	non-polymer		135.1	4	Chemie (ADE)

Sequence modifications

E, F, G, H: -229 - -12 (UniProt: P08515)

PDB	External Database	Details
Met -242	-	expression tag
Lys -241	-	expression tag
Ser -240	-	expression tag
Ser -239	-	expression tag
His -238	-	expression tag
His -237	-	expression tag
His -236	-	expression tag
His -235	-	expression tag
His -234	-	expression tag
His -233	-	expression tag
Gly -232	-	expression tag
Ser -231	-	expression tag
Ser -230	-	expression tag
Gly -11	-	linker
Ile -10	-	linker
Glu -9	-	linker
Glu -8	-	linker
Asn -7	-	linker
Leu -6	-	linker
Tyr -5	-	linker
Phe -4	-	linker
Gln -3	-	linker
Ser -2	-	linker
Asn -1	-	linker
Ala 0	-	linker

E, F, G, H: 1 - 107 (UniProt: P68106)

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	2423814.5
Non-Polymers*	Number of molecules	8
	Total formula weight	802.1
All*	Total formula weight	2424616.7

*Water molecules are not included.