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8SE9

Cryo-EM structure of a double loaded human UBA7-UBE2L6-ISG15 thioester mimetic complex (Form 2)

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Ubiquitin-like modifier-activating enzyme 7polymer1012111822.11UniProt (P41226)
Pfam (PF00899)
Pfam (PF16190)
Pfam (PF16191)
Pfam (PF10585)
Pfam (PF09358)
Homo sapiens (human)Ubiquitin-activating enzyme 7,D8,Ubiquitin-activating enzyme E1 homolog
2B, D
(B, D)
Ubiquitin-like protein ISG15polymer15717163.72UniProt (P05161)
Pfam (PF00240)
Homo sapiens (human)Interferon-induced 15 kDa protein,Interferon-induced 17 kDa protein,IP17,Ubiquitin cross-reactive protein,hUCRP
3C
(C)
Ubiquitin/ISG15-conjugating enzyme E2 L6polymer15217643.41UniProt (O14933)
Pfam (PF00179)
Homo sapiens (human)E2 ubiquitin-conjugating enzyme L6,Retinoic acid-induced gene B protein,RIG-B,UbcH8,Ubiquitin carrier protein L6,Ubiquitin-protein ligase L6
4E
(B)
ADENOSINE MONOPHOSPHATEnon-polymer347.21Chemie (AMP)
Sequence modifications
C: 2 - 153 (UniProt: O14933)
PDBExternal DatabaseDetails
Ser 98Cys 98engineered mutation
Ser 102Cys 102engineered mutation
Lys 121Leu 121engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight163792.9
Non-Polymers*Number of molecules1
Total formula weight347.2
All*Total formula weight164140.1
*Water molecules are not included.

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PDB entries from 2024-10-30

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