8SE5
NKG2D complexed with inhibitor 14
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | B, A | NKG2-D type II integral membrane protein | polymer | 129 | 14880.8 | 2 | UniProt (P26718) Pfam (PF00059) In PDB | Homo sapiens (human) | Killer cell lectin-like receptor subfamily K member 1,NK cell receptor D,NKG2-D-activating NK receptor |
| 2 | B, A | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 4 | Chemie (PGE) | |||
| 3 | B | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 4 | A | N-{(1S)-2-[(1R,5S,6S)-6-(hydroxymethyl)-3-azabicyclo[3.1.0]hexan-3-yl]-2-oxo-1-[3-(trifluoromethyl)phenyl]ethyl}-4'-(trifluoromethyl)[1,1'-biphenyl]-2-carboxamide | non-polymer | 562.5 | 1 | Chemie (ZW7) | |||
| 5 | water | water | 18.0 | 160 | Chemie (HOH) |
Sequence modifications
B, A: 90 - 216 (UniProt: P26718)
| PDB | External Database | Details |
|---|---|---|
| Met 88 | - | initiating methionine |
| Gly 89 | - | expression tag |
| Glu 117 | Ser 117 | engineered mutation |
| Ser 173 | Ile 173 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 29761.7 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1269.3 | |
| All* | Total formula weight | 31031.0 |
