8SA1
CryoEM structure of P-Glycoprotein in inward facing 2 state under continuous turnover conditions with verapamil
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | ATP-dependent translocase ABCB1 | polymer | 1280 | 141644.8 | 1 | UniProt (P08183) Pfam (PF00664) Pfam (PF00005) | Homo sapiens (human) | ATP-binding cassette sub-family B member 1,Multidrug resistance protein 1,P-glycoprotein 1,Phospholipid transporter ABCB1 |
| 2 | B, E (A) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) | |||
| 3 | C, D (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | F (A) | Dexverapamil | non-polymer | 454.6 | 1 | Chemie (I6H) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 141644.8 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1517.6 | |
| All* | Total formula weight | 143162.4 |
