8S9A
Crystal structure of the TYK2 pseudokinase domain in complex with TAK-279
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Non-receptor tyrosine-protein kinase TYK2 | polymer | 295 | 32988.4 | 3 | UniProt (P29597) Pfam (PF07714) | Homo sapiens (human) | |
| 2 | D, M, R (A, B, C) | (8S)-N-[(1R,2R)-2-methoxycyclobutyl]-7-(methylamino)-5-{[(1P,2'P)-2-oxo-2H-[1,2'-bipyridin]-3-yl]amino}pyrazolo[1,5-a]pyrimidine-3-carboxamide | non-polymer | 460.5 | 3 | Chemie (ZSB) | |||
| 3 | E, H, I, N, P... (A, B, C) | ACETATE ION | non-polymer | 59.0 | 8 | Chemie (ACT) | |||
| 4 | F, G, J, K, L... (A, B, C) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 11 | Chemie (EDO) | |||
| 5 | AA, BA, Z (B, C, A) | water | water | 18.0 | 596 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 98965.3 | |
| Non-Polymers* | Number of molecules | 22 |
| Total formula weight | 2536.6 | |
| All* | Total formula weight | 101501.9 |
