8S99
Crystal structure of the TYK2 pseudokinase domain in complex with compound 11
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C | Non-receptor tyrosine-protein kinase TYK2 | polymer | 295 | 32988.4 | 3 | UniProt (P29597) Pfam (PF07714) In PDB | Homo sapiens (human) | |
| 2 | A, B, C | (8S)-N-[(1R,2S)-2-fluorocyclopropyl]-5-{[(1M,2'M)-3'-fluoro-2-oxo-2H-[1,2'-bipyridin]-3-yl]amino}-7-(methylamino)pyrazolo[1,5-a]pyrimidine-3-carboxamide | non-polymer | 452.4 | 3 | Chemie (ZS3) | |||
| 3 | A, B, C | 1,2-ETHANEDIOL | non-polymer | 62.1 | 6 | Chemie (EDO) | |||
| 4 | A, B, C | ACETATE ION | non-polymer | 59.0 | 3 | Chemie (ACT) | |||
| 5 | water | water | 18.0 | 671 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 98965.3 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 1906.8 | |
| All* | Total formula weight | 100872.1 |
