8S8W
SARS-CoV-2 nsp10-16 methyltransferase in complex with Sangivamycin and m7GpppA-RNA (Cap0-RNA)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 2'-O-methyltransferase nsp16 | polymer | 304 | 34150.1 | 1 | UniProt (P0DTD1) Pfam (PF06460) | Severe acute respiratory syndrome coronavirus 2 | Non-structural protein 16,nsp16 |
| 2 | B (B) | Non-structural protein 10 | polymer | 140 | 14860.0 | 1 | UniProt (P0DTD1) Pfam (PF09401) | Severe acute respiratory syndrome coronavirus 2 | nsp10,Growth factor-like peptide,GFL |
| 3 | C (C) | m7GpppA-RNA (Cap0-RNA) | polymer | 3 | 896.6 | 1 | synthetic construct | ||
| 4 | D (A) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) | |||
| 5 | E (A) | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 1 | Chemie (SAM) | |||
| 6 | F (A) | SANGIVAMYCIN | non-polymer | 309.3 | 1 | Chemie (SGV) | |||
| 7 | G, H, I (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 8 | J, K (B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 9 | L (C) | P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE | non-polymer | 787.4 | 1 | Chemie (GTA) | |||
| 10 | M, N, O (A, B, C) | water | water | 18.0 | 183 | Chemie (HOH) |
Sequence modifications
A: 6799 - 7096 (UniProt: P0DTD1)
B: 4254 - 4392 (UniProt: P0DTD1)
| PDB | External Database | Details |
|---|---|---|
| Glu 7097 | - | expression tag |
| Asn 7098 | - | expression tag |
| Leu 7099 | - | expression tag |
| Tyr 7100 | - | expression tag |
| Phe 7101 | - | expression tag |
| Gln 7102 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 4253 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 49906.7 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 2007.4 | |
| All* | Total formula weight | 51914.1 |
