8S85
Crystal structure of JAK1 JH1 domain in complex with an inhibitor
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Tyrosine-protein kinase JAK1 | polymer | 302 | 34746.6 | 2 | UniProt (P23458) Pfam (PF07714) | Homo sapiens (human) | Janus kinase 1,JAK-1 |
| 2 | C, G (A, B) | ~{N}-(2-ethylphenyl)-~{N},1-dimethyl-imidazo[4,5-c]pyridin-6-amine | non-polymer | 266.3 | 2 | Chemie (A1H5R) | |||
| 3 | D, E, F (A) | SODIUM ION | non-polymer | 23.0 | 3 | Chemie (NA) | |||
| 4 | H, I (A, B) | water | water | 18.0 | 438 | Chemie (HOH) |
Sequence modifications
A, B: 854 - 1154 (UniProt: P23458)
| PDB | External Database | Details |
|---|---|---|
| Gly 853 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 69493.2 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 601.7 | |
| All* | Total formula weight | 70094.8 |
