8S7V

Methyl-coenzyme M reductase activation complex binding to the A2 component

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Methyl-coenzyme M reductase subunit gamma	polymer	260	29665.5	2	UniProt (A0A2L1CBG2) Pfam (PF02240)	Methanococcus maripaludis
2	C, D (E, D)	Methyl-coenzyme M reductase subunit beta	polymer	443	46701.2	2	UniProt (A0A2L1CBB3) Pfam (PF02783) Pfam (PF02241)	Methanococcus maripaludis	Coenzyme-B sulfoethylthiotransferase beta
3	E, G (C, F)	Methyl-coenzyme M reductase subunit alpha	polymer	553	61230.7	2	UniProt (A0A2L1CBB0) Pfam (PF02745) Pfam (PF02249)	Methanococcus maripaludis
4	F (G)	Methanogenesis marker protein 17	polymer	183	21119.5	1	UniProt (G0H411) Pfam (PF09886)	Methanococcus maripaludis	Mmp17
5	H (H)	Methanogenesis marker protein 7	polymer	304	35024.7	1	UniProt (G0H350) Pfam (PF04609)	Methanococcus maripaludis	Mmp7
6	I (I)	Methyl-coenzyme M reductase operon protein C	polymer	234	24906.7	1	UniProt (G0H3B1) Pfam (PF04609)	Methanococcus maripaludis	McrC
7	J (K)	Glycine betaine/carnitine/choline transport ATP-binding protein OpuCA	polymer	531	59572.6	1	UniProt (A0A2L1C9A1) Pfam (PF00005)	Methanococcus maripaludis	Methyl coenzyme M reductase system subunit A2
8	K (J)	UPF0288 protein MmarC6_0796	polymer	501	56520.8	1	UniProt (A9A8E0) UniProt (by SIFTS) (A0A7J9PIK9)	Methanococcus maripaludis	Methanogenesis marker protein 3,Mmp3
9	L (L)	DUF2098 domain-containing protein	polymer	93	10640.8	1	UniProt (A0A2L1CAX0) Pfam (PF09871)	Methanococcus maripaludis
10	M (E)	O-PHOSPHONO-N-{(2E)-7-[(2-SULFOETHYL)DITHIO]HEPT-2-ENOYL}-L-THREONINE	non-polymer		481.5	1	Chemie (SHT)
11	N (C)	Coenzyme B	non-polymer		343.3	1	Chemie (TP7)
12	O (C)	1-THIOETHANESULFONIC ACID	non-polymer		142.2	1	Chemie (COM)
13	P, Q (F)	FACTOR 430	non-polymer		906.6	2	Chemie (F43)
14	R, S, T (H, I)	FeFe cofactor	non-polymer		747.4	3	Chemie (S5Q)
15	U (K)	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
16	V, W (K)	ADENOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	2	Chemie (ATP)
17	X, Y (K)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)

Sequence modifications

E, D: 1 - 443 (UniProt: A0A2L1CBB3)

PDB	External Database	Details
Gly 173	Ser 173	conflict

C, F: 1 - 553 (UniProt: A0A2L1CBB0)

PDB	External Database	Details
Ser 51	Ala 51	variant

G: 1 - 184 (UniProt: G0H411)

PDB	External Database	Details
Val 109	Ile 109	variant
Ile 129	Val 129	variant
Glu 167	Gln 166	variant
Glu 168	Asp 167	variant
Asn 171	Asp 170	variant

H: 1 - 304 (UniProt: G0H350)

PDB	External Database	Details
Asn 115	Ser 115	variant
Glu 260	Lys 260	variant

I: 1 - 198 (UniProt: G0H3B1)

PDB	External Database	Details
Met -35	-	initiating methionine
Ser -34	-	expression tag
Ala -33	-	expression tag
Trp -32	-	expression tag
Ser -31	-	expression tag
His -30	-	expression tag
Pro -29	-	expression tag
Gln -28	-	expression tag
Phe -27	-	expression tag
Glu -26	-	expression tag
Lys -25	-	expression tag
Gly -24	-	expression tag
Gly -23	-	expression tag
Gly -22	-	expression tag
Ser -21	-	expression tag
Gly -20	-	expression tag
Gly -19	-	expression tag
Gly -18	-	expression tag
Ser -17	-	expression tag
Gly -16	-	expression tag
Gly -15	-	expression tag
Ser -14	-	expression tag
Ala -13	-	expression tag
Trp -12	-	expression tag
Ser -11	-	expression tag
His -10	-	expression tag
Pro -9	-	expression tag
Gln -8	-	expression tag
Phe -7	-	expression tag
Glu -6	-	expression tag
Lys -5	-	expression tag
Ser -4	-	expression tag
Ala -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
Gly 0	-	expression tag

J: 1 - 501 (UniProt: A9A8E0)

PDB	External Database	Details
Ser 500	Lys 500	variant

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	482980.0
Non-Polymers*	Number of molecules	13
	Total formula weight	6150.6
All*	Total formula weight	489130.6

*Water molecules are not included.