8S72
Crystal structure of neutralizing Fab Eq4.Dp46-3D from equine antivenom bound to a consensus short chain three finger alpha-neurotoxin.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (N, A) | Short neurotoxin 1 | polymer | 64 | 7117.2 | 2 | UniProt (P01426) Pfam (PF21947) | synthetic construct | Neurotoxin alpha,Toxin alpha |
| 2 | C, E (X, H) | Heavy chain of Fab domain from antivenom neutralizing antibody Eq4.Dp46-3D. | polymer | 233 | 24573.7 | 2 | Equus caballus | ||
| 3 | D, F (Y, L) | Light chain of Fab domain from antivenom neutralizing antibody Eq4.Dp46-3D. | polymer | 217 | 22803.0 | 2 | Equus caballus | ||
| 4 | G, H, I, J, K... (N, A, X, Y, H...) | water | water | 18.0 | 204 | Chemie (HOH) |
Sequence modifications
N, A: 1 - 60 (UniProt: P01426)
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Pro -2 | - | expression tag |
| Gly -1 | - | linker |
| Gly 0 | - | linker |
| Met 1 | Leu 1 | conflict |
| Ile 2 | Glu 2 | conflict |
| Tyr 4 | His 4 | engineered mutation |
| - | Pro 18 | deletion |
| Ser 18 | Gly 19 | engineered mutation |
| Ser 21 | Asn 22 | engineered mutation |
| Thr 26 | Val 27 | engineered mutation |
| Lys 43 | Thr 44 | engineered mutation |
| His 51 | Asn 52 | engineered mutation |
| Arg 54 | Thr 55 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 108987.8 | |
| All* | Total formula weight | 108987.8 |
