8S61
Cryo-EM structure of thiamine-bound human SLC19A3 in inward-open state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Nb3.7 | polymer | 122 | 13296.8 | 1 | Lama glama | ||
| 2 | B (A) | Thiamine transporter 2 | polymer | 449 | 50507.7 | 1 | UniProt (Q9BZV2) Pfam (PF01770) | Homo sapiens (human) | ThTr-2,ThTr2,Solute carrier family 19 member 3 |
| 3 | C (A) | 3-(4-AMINO-2-METHYL-PYRIMIDIN-5-YLMETHYL)-5-(2-HYDROXY-ETHYL)-4-METHYL-THIAZOL-3-IUM | non-polymer | 265.4 | 1 | Chemie (VIB) |
Sequence modifications
A: 11 - 459 (UniProt: Q9BZV2)
| PDB | External Database | Details |
|---|---|---|
| Gln 45 | Asn 45 | engineered mutation |
| Gln 166 | Asn 166 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 63804.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 265.4 | |
| All* | Total formula weight | 64069.8 |
