8S4W
Tankyrase 2 in complex with a quinazolin-4-one inhibitor
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Poly [ADP-ribose] polymerase tankyrase-2 | polymer | 171 | 19482.1 | 1 | UniProt (Q9H2K2) Pfam (PF00644) | Homo sapiens (human) | ADP-ribosyltransferase diphtheria toxin-like 6,ARTD6,Poly [ADP-ribose] polymerase 5B,Protein poly-ADP-ribosyltransferase tankyrase-2,TNKS-2,TRF1-interacting ankyrin-related ADP-ribose polymerase 2,Tankyrase II,Tankyrase-2,TANK2,Tankyrase-like protein,Tankyrase-related protein |
| 2 | B (E) | Poly [ADP-ribose] polymerase tankyrase-2 | polymer | 48 | 5364.0 | 1 | UniProt (Q9H2K2) | Homo sapiens (human) | ADP-ribosyltransferase diphtheria toxin-like 6,ARTD6,Poly [ADP-ribose] polymerase 5B,Protein poly-ADP-ribosyltransferase tankyrase-2,TNKS-2,TRF1-interacting ankyrin-related ADP-ribose polymerase 2,Tankyrase II,Tankyrase-2,TANK2,Tankyrase-like protein,Tankyrase-related protein |
| 3 | C (A) | (2~{R})-~{N}-[2-(4-~{tert}-butylphenyl)-4-oxidanylidene-3~{H}-quinazolin-8-yl]-2,3-bis(oxidanyl)propanamide | non-polymer | 381.4 | 1 | Chemie (A1H44) | |||
| 4 | D (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 5 | E, F (A) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 6 | G, H (A, E) | water | water | 18.0 | 86 | Chemie (HOH) |
Sequence modifications
A: 946 - 1114 (UniProt: Q9H2K2)
| PDB | External Database | Details |
|---|---|---|
| Ser 944 | - | expression tag |
| Met 945 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 24846.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 639.0 | |
| All* | Total formula weight | 25485.0 |
