Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Mast/stem cell growth factor receptor Kit | polymer | 327 | 37194.4 | 2 | UniProt (P10721) Pfam (PF07714) | Homo sapiens (human) | SCFR,Piebald trait protein,PBT,Proto-oncogene c-Kit,Tyrosine-protein kinase Kit,p145 c-kit,v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog |
| 2 | C, E (A, B) | 3-[2-[2-(cyclopropylamino)pyrimidin-5-yl]ethynyl]-~{N}-[3-imidazol-1-yl-5-(trifluoromethyl)phenyl]-4-methyl-benzamide | non-polymer | 502.5 | 2 | Chemie (A1H4U) | |||
| 3 | D (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 243 | Chemie (HOH) |
Sequence modifications
A, B: 551 - 687 (UniProt: P10721)
A, B: 766 - 934 (UniProt: P10721)
| PDB | External Database | Details |
|---|---|---|
| Gly 548 | - | expression tag |
| Ser 549 | - | expression tag |
| Met 550 | - | expression tag |
| Ser 563 | Ile 563 | engineered mutation |
| Ser 569 | Val 569 | engineered mutation |
| Gln 609 | Tyr 609 | engineered mutation |
| Ser 631 | Leu 631 | engineered mutation |
| Glu 651 | Met 651 | engineered mutation |
| His 662 | Ile 662 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Glu 688 | - | linker |
| Phe 689 | - | linker |
| Val 690 | - | linker |
| Pro 691 | - | linker |
| Tyr 692 | - | linker |
| Lys 693 | - | linker |
| Val 694 | - | linker |
| Ala 695 | - | linker |
| Pro 756 | - | linker |
| Glu 757 | - | linker |
| Asp 758 | - | linker |
| Leu 759 | - | linker |
| Tyr 760 | - | linker |
| Lys 761 | - | linker |
| Asp 762 | - | linker |
| Phe 763 | - | linker |
| Leu 764 | - | linker |
| Thr 765 | - | linker |
| His 768 | Asp 768 | engineered mutation |
| Asn 804 | Arg 804 | engineered mutation |
| Asp 825 | Val 825 | engineered mutation |
| Ser 844 | Cys 844 | engineered mutation |
| Ser 890 | Leu 890 | engineered mutation |
| Tyr 894 | His 894 | engineered mutation |
| Asp 912 | Leu 912 | engineered mutation |
| Asp 923 | Leu 923 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 74388.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1040.4 | |
| All* | Total formula weight | 75429.3 |
