8S0N

Crystal structure of the TMPRSS2 zymogen in complex with the nanobody A07

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	Transmembrane protease serine 2	polymer	397	43922.4	2	UniProt (O15393) Pfam (PF15494) Pfam (PF00089) In PDB	Homo sapiens (human)	Serine protease 10
2	B, D	nanobody A07	polymer	150	16031.5	2		Vicugna pacos
3		water	water		18.0	209	Chemie (HOH)

Sequence modifications

A, C: 107 - 492 (UniProt: O15393)

PDB	External Database	Details
Arg 105	-	expression tag
Ser 106	-	expression tag
Ala 441	Ser 441	engineered mutation
Gly 493	-	expression tag
Pro 494	-	expression tag
Phe 495	-	expression tag
Glu 496	-	expression tag
Asp 497	-	expression tag
Asp 498	-	expression tag
Asp 499	-	expression tag
Asp 500	-	expression tag
Lys 501	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	119907.9
All*	Total formula weight	119907.9

*Water molecules are not included.