8RV5

SARS-CoV-2 nsp16-nsp10 in complex with SAM derivative inhibitor 1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	2'-O-methyltransferase nsp16	polymer	302	33701.6	1	UniProt (P0DTD1) Pfam (PF06460) In PDB	Severe acute respiratory syndrome coronavirus 2	Non-structural protein 16,nsp16
2	B	Non-structural protein 10	polymer	142	15078.3	1	UniProt (P0DTC1) Pfam (PF09401) UniProt (by SIFTS) (P0DTD1) In PDB	Severe acute respiratory syndrome coronavirus 2	nsp10,Growth factor-like peptide,GFL
3	A	2-(N-MORPHOLINO)-ETHANESULFONIC ACID	non-polymer		195.2	1	Chemie (MES)
4	A	5'-DEOXY-5'-METHYLTHIOADENOSINE	non-polymer		297.3	1	Chemie (MTA)
5	B	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
6		water	water		18.0	242	Chemie (HOH)

Sequence modifications

A: 1 - 298 (UniProt: P0DTD1)

PDB	External Database	Details
Gly -3	-	expression tag
Ser -2	-	expression tag
Met -1	-	expression tag
Ala 0	-	expression tag

B: 1 - 139 (UniProt: P0DTC1)

PDB	External Database	Details
Gly -2	-	expression tag
Ser -1	-	expression tag
Met 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	48779.9
Non-Polymers*	Number of molecules	4
	Total formula weight	623.4
All*	Total formula weight	49403.3

*Water molecules are not included.