8RRZ
Crystal structure of SYK kinase in complex with compound 1
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein kinase SYK | polymer | 282 | 32867.7 | 1 | UniProt (P43405) Pfam (PF07714) | Homo sapiens (human) | Spleen tyrosine kinase,p72-Syk |
| 2 | B (A) | N-[(2S)-1-(azetidin-1-yl)propan-2-yl]-3-{2-[(3,5-dimethoxyphenyl)amino]pyrimidin-4-yl}-1-methyl-1H-pyrazole-5-carboxamide | non-polymer | 451.5 | 1 | Chemie (A1H2Y) | |||
| 3 | C, D (A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 4 | E (A) | water | water | 18.0 | 129 | Chemie (HOH) |
Sequence modifications
A: 355 - 635 (UniProt: P43405)
| PDB | External Database | Details |
|---|---|---|
| Gly 354 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32867.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 635.7 | |
| All* | Total formula weight | 33503.4 |
