8RR4
Human mitochondrial RNase Z complex with ELAC2-D550N catalytic mutant with ordered flexible arm and tRNA-Tyr precursor - (Composite model)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | 3-hydroxyacyl-CoA dehydrogenase type-2 | polymer | 261 | 26947.0 | 4 | UniProt (Q99714) Pfam (PF00106) | Homo sapiens (human) | 17-beta-estradiol 17-dehydrogenase,2-methyl-3-hydroxybutyryl-CoA dehydrogenase,MHBD,3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+)),3-hydroxy-2-methylbutyryl-CoA dehydrogenase,3-hydroxyacyl-CoA dehydrogenase type II,3alpha(or 20beta)-hydroxysteroid dehydrogenase,7-alpha-hydroxysteroid dehydrogenase,Endoplasmic reticulum-associated amyloid beta-peptide-binding protein,Mitochondrial ribonuclease P protein 2,Mitochondrial RNase P protein 2,Short chain dehydrogenase/reductase family 5C member 1,Short-chain type dehydrogenase/reductase XH98G2,Type II HADH |
| 2 | E (E) | Zinc phosphodiesterase ELAC protein 2 | polymer | 798 | 89169.3 | 1 | UniProt (Q9BQ52) Pfam (PF13691) Pfam (PF12706) | Homo sapiens (human) | ElaC homolog protein 2,Heredity prostate cancer protein 2,Ribonuclease Z 2,RNase Z 2,tRNA 3 endonuclease 2,tRNase Z 2 |
| 3 | F (F) | tRNA methyltransferase 10 homolog C | polymer | 315 | 37165.1 | 1 | UniProt (Q7L0Y3) Pfam (PF01746) | Homo sapiens (human) | HBV pre-S2 trans-regulated protein 2,Mitochondrial ribonuclease P protein 1,Mitochondrial RNase P protein 1,RNA (guanine-9-)-methyltransferase domain-containing protein 1,Renal carcinoma antigen NY-REN-49,mRNA methyladenosine-N(1)-methyltransferase,tRNA (adenine(9)-N(1))-methyltransferase,tRNA (guanine(9)-N(1))-methyltransferase |
| 4 | G (T) | Human mitochondria tRNA-Tyr precursor with 3' trailer | polymer | 90 | 29023.2 | 1 | GenBank (1851980274) | Homo sapiens | |
| 5 | H, I (E) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 6 | J (F) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 1 | Chemie (SAH) |
Sequence modifications
E: 32 - 826 (UniProt: Q9BQ52)
F: 92 - 403 (UniProt: Q7L0Y3)
T: 1 - 84 (GenBank: 1851980274)
| PDB | External Database | Details |
|---|---|---|
| Ser 29 | - | expression tag |
| Asn 30 | - | expression tag |
| Ala 31 | - | expression tag |
| Asn 550 | Asp 550 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ser 89 | - | expression tag |
| Asn 90 | - | expression tag |
| Ala 91 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| A 85 | - | expression tag |
| G 86 | - | expression tag |
| C 87 | - | expression tag |
| U 88 | - | expression tag |
| C 89 | - | expression tag |
| G 90 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 7 |
| Total formula weight | 263145.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 515.2 | |
| All* | Total formula weight | 263660.9 |
