8RR1
Human mitochondrial RNase Z complex with ELAC2-D550N catalytic mutant and tRNA-Tyr precursor (Composite model)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | 3-hydroxyacyl-CoA dehydrogenase type-2 | polymer | 261 | 26947.0 | 4 | UniProt (Q99714) Pfam (PF00106) | Homo sapiens (human) | 17-beta-estradiol 17-dehydrogenase,2-methyl-3-hydroxybutyryl-CoA dehydrogenase,MHBD,3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+)),3-hydroxy-2-methylbutyryl-CoA dehydrogenase,3-hydroxyacyl-CoA dehydrogenase type II,3alpha(or 20beta)-hydroxysteroid dehydrogenase,7-alpha-hydroxysteroid dehydrogenase,Endoplasmic reticulum-associated amyloid beta-peptide-binding protein,Mitochondrial ribonuclease P protein 2,Mitochondrial RNase P protein 2,Short chain dehydrogenase/reductase family 5C member 1,Short-chain type dehydrogenase/reductase XH98G2,Type II HADH |
| 2 | E (E) | Zinc phosphodiesterase ELAC protein 2 | polymer | 798 | 89169.3 | 1 | UniProt (Q9BQ52) Pfam (PF13691) Pfam (PF23023) | Homo sapiens (human) | ElaC homolog protein 2,Heredity prostate cancer protein 2,Ribonuclease Z 2,RNase Z 2,tRNA 3 endonuclease 2,tRNase Z 2 |
| 3 | F (F) | tRNA methyltransferase 10 homolog C | polymer | 315 | 37165.1 | 1 | UniProt (Q7L0Y3) | Homo sapiens (human) | HBV pre-S2 trans-regulated protein 2,Mitochondrial ribonuclease P protein 1,Mitochondrial RNase P protein 1,RNA (guanine-9-)-methyltransferase domain-containing protein 1,Renal carcinoma antigen NY-REN-49,mRNA methyladenosine-N(1)-methyltransferase,tRNA (adenine(9)-N(1))-methyltransferase,tRNA (guanine(9)-N(1))-methyltransferase |
| 4 | G (T) | Human mitochondrial tRNA-Tyr precursor with 3' trailer | polymer | 90 | 29023.2 | 1 | Homo sapiens | ||
| 5 | H, I (E) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 6 | J (F) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 1 | Chemie (SAH) PubChem (193) PubChem (13792) PubChem (189149) PubChem (439155) PubChem (5284331) PubChem (71170554) PubChem (13231890) PubChem (16760024) PubChem (25210495) PubChem (44361184) PubChem (177678424) PubChem (46936206) PubChem (21125603) PubChem (25203782) PubChem (52224400) PubChem (50989525) PubChem (51380914) PubChem (52224398) PubChem (6419189) PubChem (57544532) PubChem (59046843) PubChem (59170628) PubChem (164157219) PubChem (59576228) PubChem (66805708) PubChem (70689219) PubChem (70702054) PubChem (70832431) PubChem (118374891) PubChem (118560068) PubChem (126969526) PubChem (129105892) PubChem (143518505) PubChem (154578335) PubChem (163054214) PubChem (163335525) |
Sequence modifications
E: 32 - 826 (UniProt: Q9BQ52)
F: 92 - 403 (UniProt: Q7L0Y3)
| PDB | External Database | Details |
|---|---|---|
| Ser 29 | - | expression tag |
| Asn 30 | - | expression tag |
| Ala 31 | - | expression tag |
| Asn 550 | Asp 550 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ser 89 | - | expression tag |
| Asn 90 | - | expression tag |
| Ala 91 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 7 |
| Total formula weight | 263145.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 515.2 | |
| All* | Total formula weight | 263660.9 |
