8RQO

Human thyroid hormone receptor alpha ligand binding domain in complex with beta-selective agonist ALG-055009

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Isoform Alpha-1 of Thyroid hormone receptor alpha	polymer	284	32251.1	1	UniProt (P10827) Pfam (PF00104)	Homo sapiens (human)	Nuclear receptor subfamily 1 group A member 1,V-erbA-related protein 7,EAR-7,c-erbA-1,c-erbA-alpha
2	B (A)	6-azanyl-2-[3,5-bis(chloranyl)-4-[(6-oxidanylidene-5-propan-2-yl-1~{H}-pyridazin-3-yl)oxy]phenyl]-1,2,4-triazine-3,5-dione	non-polymer		425.2	1	Chemie (A1H2J)
3	C (A)	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
4	D (A)	water	water		18.0	14	Chemie (HOH)

Sequence modifications

A: 148 - 410 (UniProt: P10827)

PDB	External Database	Details
Met 127	-	initiating methionine
Gly 128	-	expression tag
Ser 129	-	expression tag
Ser 130	-	expression tag
His 131	-	expression tag
His 132	-	expression tag
His 133	-	expression tag
His 134	-	expression tag
His 135	-	expression tag
His 136	-	expression tag
Ser 137	-	expression tag
Ser 138	-	expression tag
Gly 139	-	expression tag
Leu 140	-	expression tag
Val 141	-	expression tag
Pro 142	-	expression tag
Arg 143	-	expression tag
Gly 144	-	expression tag
Ser 145	-	expression tag
His 146	-	expression tag
Met 147	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	32251.1
Non-Polymers*	Number of molecules	2
	Total formula weight	521.3
All*	Total formula weight	32772.4

*Water molecules are not included.