8RQN

Human thyroid hormone receptor beta ligand binding domain in complex with beta-selective agonist ALG-055009

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Thyroid hormone receptor beta	polymer	281	31833.5	1	UniProt (P10828) Pfam (PF00104)	Homo sapiens (human)	Nuclear receptor subfamily 1 group A member 2,c-erbA-2,c-erbA-beta
2	B (A)	6-azanyl-2-[3,5-bis(chloranyl)-4-[(6-oxidanylidene-5-propan-2-yl-1~{H}-pyridazin-3-yl)oxy]phenyl]-1,2,4-triazine-3,5-dione	non-polymer		425.2	1	Chemie (A1H2J)

Sequence modifications

A: 202 - 461 (UniProt: P10828)

PDB	External Database	Details
Met 181	-	initiating methionine
Gly 182	-	expression tag
Ser 183	-	expression tag
Ser 184	-	expression tag
His 185	-	expression tag
His 186	-	expression tag
His 187	-	expression tag
His 188	-	expression tag
His 189	-	expression tag
His 190	-	expression tag
Ser 191	-	expression tag
Ser 192	-	expression tag
Gly 193	-	expression tag
Leu 194	-	expression tag
Val 195	-	expression tag
Pro 196	-	expression tag
Arg 197	-	expression tag
Gly 198	-	expression tag
Ser 199	-	expression tag
His 200	-	expression tag
Met 201	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	31833.5
Non-Polymers*	Number of molecules	1
	Total formula weight	425.2
All*	Total formula weight	32258.8

*Water molecules are not included.