8RQL
TAS2R14 receptor bound to flufenamic acid and gustducin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (R) | Taste receptor type 2 member 14 | polymer | 317 | 36200.1 | 1 | UniProt (Q9NYV8) Pfam (PF05296) | Homo sapiens (human) | T2R14,Taste receptor family B member 1,TRB1 |
| 2 | B (A) | Guanine nucleotide-binding protein G(t) subunit alpha-3 | polymer | 229 | 25983.6 | 1 | UniProt (A8MTJ3) Pfam (PF00503) | Homo sapiens (human) | Gustducin alpha-3 chain |
| 3 | C (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 358 | 39418.1 | 1 | UniProt (P62873) Pfam (PF25391) | Homo sapiens (human) | Transducin beta chain 1 |
| 4 | D (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 5 | E (S) | scFv16 | polymer | 256 | 27340.5 | 1 | Mus musculoides | ||
| 6 | F, G (R) | 2-[[3-(TRIFLUOROMETHYL)PHENYL]AMINO] BENZOIC ACID | non-polymer | 281.2 | 2 | Chemie (FLF) |
Sequence modifications
A: 1 - 57 (UniProt: A8MTJ3)
A: 66 - 229 (UniProt: A8MTJ3)
B: 19 - 357 (UniProt: P62873)
| PDB | External Database | Details |
|---|---|---|
| Thr 4 | Gly 4 | conflict |
| Val 5 | Ile 5 | conflict |
| Ala 7 | Ser 7 | conflict |
| Asp 9 | Ser 9 | conflict |
| Ala 11 | Glu 11 | conflict |
| Ala 12 | Ser 12 | conflict |
| Glu 14 | Lys 14 | conflict |
| Asp 42 | Gly 42 | conflict |
| Asn 43 | Glu 43 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Gly 58 | - | linker |
| Gly 59 | - | linker |
| Ser 60 | - | linker |
| Gly 61 | - | linker |
| Gly 62 | - | linker |
| Ser 63 | - | linker |
| Gly 64 | - | linker |
| Gly 65 | - | linker |
| Asp 102 | Gly 217 | conflict |
| Asp 111 | Ala 226 | conflict |
| Asp 114 | Ala 229 | conflict |
| - | Asp 231 | deletion |
| - | Met 232 | deletion |
| - | Val 233 | deletion |
| - | Leu 234 | deletion |
| - | Val 235 | deletion |
| - | Glu 236 | deletion |
| - | Asp 237 | deletion |
| - | Glu 238 | deletion |
| - | Glu 239 | deletion |
| - | Val 240 | deletion |
| Ala 207 | Val 332 | conflict |
| Ile 210 | Val 335 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| His 1 | - | expression tag |
| His 2 | - | expression tag |
| His 3 | - | expression tag |
| His 4 | - | expression tag |
| His 5 | - | expression tag |
| His 6 | - | expression tag |
| Leu 7 | - | expression tag |
| Glu 8 | - | expression tag |
| Val 9 | - | expression tag |
| Leu 10 | - | expression tag |
| Phe 11 | - | expression tag |
| Gln 12 | - | expression tag |
| Gly 13 | - | expression tag |
| Pro 14 | - | expression tag |
| Gly 15 | - | expression tag |
| Ser 16 | - | expression tag |
| Ser 17 | - | expression tag |
| Gly 18 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 136803.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 562.5 | |
| All* | Total formula weight | 137365.8 |
