8RPN

hJAK3 in complex with LAW931 inhibitor

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Tyrosine-protein kinase JAK3	polymer	298	34023.7	4	UniProt (P52333) Pfam (PF07714)	Homo sapiens (human)	Janus kinase 3,JAK-3,Leukocyte janus kinase,L-JAK
2	E, F, G, H (A, B, C, D)	3-[4-[[(3~{R})-1-(2-cyanoethanoyl)piperidin-3-yl]amino]pyrimidin-2-yl]imidazo[1,2-a]pyridine-6-carbonitrile	non-polymer		386.4	4	Chemie (A1H2B)
3	I, J, K, L (A, B, C, D)	water	water		18.0	13	Chemie (HOH)

Sequence modifications

A, B, C, D: 816 - 1111 (UniProt: P52333)

PDB	External Database	Details
Pro 814	-	expression tag
Thr 815	-	expression tag
Ser 1048	Cys 1048	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	136094.9
Non-Polymers*	Number of molecules	4
	Total formula weight	1545.6
All*	Total formula weight	137640.5

*Water molecules are not included.