8RO1
Structure of the C. elegans Intron Lariat Spliceosome double-primed for disassembly (ILS'')
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (2) | U2 snRNA | polymer | 228 | 68422.4 | 1 | Caenorhabditis elegans | ||
| 2 | B (5) | U5 snRNA | polymer | 112 | 35826.1 | 1 | Caenorhabditis elegans | ||
| 3 | C (6) | U6 snRNA | polymer | 101 | 32483.4 | 1 | Caenorhabditis elegans | ||
| 4 | D (A) | Pre-mRNA-splicing factor 8 homolog | polymer | 2329 | 272396.2 | 1 | UniProt (P34369) Pfam (PF08082) Pfam (PF08083) Pfam (PF10598) Pfam (PF10597) Pfam (PF10596) Pfam (PF12134) Pfam (PF01398) Pfam (PF08084) | Caenorhabditis elegans | |
| 5 | E (C) | Tr-type G domain-containing protein | polymer | 974 | 110612.9 | 1 | UniProt (Q23463) Pfam (PF00009) Pfam (PF03144) Pfam (PF03764) Pfam (PF00679) Pfam (PF16004) | Caenorhabditis elegans | |
| 6 | F (D) | Protein isy-1 | polymer | 267 | 31326.2 | 1 | UniProt (Q20716) Pfam (PF06246) | Caenorhabditis elegans | |
| 7 | G (DX) | Pre-mRNA-splicing factor ATP-dependent RNA helicase ddx-15 | polymer | 739 | 84495.5 | 1 | UniProt (Q20875) Pfam (PF00270) Pfam (PF00271) Pfam (PF04408) Pfam (PF21010) Pfam (PF07717) | Caenorhabditis elegans | DEAH box protein 15 |
| 8 | H (E) | WD_REPEATS_REGION domain-containing protein | polymer | 331 | 36865.6 | 1 | UniProt (Q19211) Pfam (PF00400) | Caenorhabditis elegans | |
| 9 | I (I) | Pre-mRNA-splicing factor SYF1 | polymer | 855 | 99675.1 | 1 | UniProt (P91175) Pfam (PF23233) Pfam (PF23220) Pfam (PF23231) | Caenorhabditis elegans | |
| 10 | J (IN) | Intron lariat RNA | polymer | 51 | 10348.2 | 1 | Caenorhabditis elegans | ||
| 11 | K (J) | TPR_REGION domain-containing protein | polymer | 744 | 88116.0 | 1 | UniProt (O16376) Pfam (PF23241) Pfam (PF02184) Pfam (PF23231) | Caenorhabditis elegans | |
| 12 | L (K) | Pre-mRNA-splicing factor SPF27 | polymer | 238 | 27679.9 | 1 | UniProt (Q22417) Pfam (PF05700) | Caenorhabditis elegans | |
| 13 | M (L) | Cell division cycle 5-like protein | polymer | 755 | 85843.5 | 1 | UniProt (G5EFC4) Pfam (PF13921) Pfam (PF11831) | Caenorhabditis elegans | |
| 14 | N (L1) | CWF19-like protein 1 homolog | polymer | 533 | 59034.9 | 1 | UniProt (O16216) Pfam (PF04677) Pfam (PF04676) | Caenorhabditis elegans | |
| 15 | O (L2) | CWF19-like protein 2 homolog | polymer | 460 | 53269.2 | 1 | UniProt (Q10946) Pfam (PF04677) Pfam (PF04676) | Caenorhabditis elegans | |
| 16 | P (M) | Pre-mRNA-splicing factor syf-2 | polymer | 234 | 27719.0 | 1 | UniProt (Q09385) Pfam (PF08231) | Caenorhabditis elegans | |
| 17 | Q (N) | Protein BUD31 homolog | polymer | 147 | 17153.9 | 1 | UniProt (P34313) Pfam (PF01125) | Caenorhabditis elegans | Protein G10 homolog |
| 18 | R (O) | Pre-mRNA-splicing factor RBM22 | polymer | 408 | 45902.8 | 1 | UniProt (Q22412) Pfam (PF21369) Pfam (PF25584) Pfam (PF00076) | Caenorhabditis elegans | RNA-binding motif protein 22 |
| 19 | S (P) | Spliceosome-associated protein CWC15 homolog | polymer | 230 | 26154.8 | 1 | UniProt (O45766) Pfam (PF04889) | Caenorhabditis elegans | |
| 20 | T (PX) | GCF C-terminal domain-containing protein | polymer | 809 | 94244.9 | 1 | UniProt (G5ECH1) Pfam (PF15458) Pfam (PF07842) | Caenorhabditis elegans | |
| 21 | U (Q) | Intron-binding protein aquarius | polymer | 1467 | 170397.7 | 1 | UniProt (Q9U1Q7) Pfam (PF16399) Pfam (PF21143) Pfam (PF21144) Pfam (PF13086) Pfam (PF13087) | Caenorhabditis elegans | |
| 22 | V (R) | Uncharacterized protein T27F2.1 | polymer | 535 | 60303.5 | 1 | UniProt (Q22836) Pfam (PF02731) | Caenorhabditis elegans | |
| 23 | W (S) | Peptidyl-prolyl cis-trans isomerase | polymer | 169 | 18547.0 | 1 | UniProt (Q18445) Pfam (PF00160) | Caenorhabditis elegans | PPIase |
| 24 | X (T) | WD_REPEATS_REGION domain-containing protein | polymer | 494 | 54766.2 | 1 | UniProt (G5EEL2) Pfam (PF00400) | Caenorhabditis elegans | |
| 25 | Y (TF) | Septin and tuftelin-interacting protein 1 homolog | polymer | 830 | 94421.5 | 1 | UniProt (Q17784) Pfam (PF12457) Pfam (PF01585) Pfam (PF07842) | Caenorhabditis elegans | STIP-1 |
| 26 | Z (W) | WD_REPEATS_REGION domain-containing protein | polymer | 567 | 65385.7 | 1 | UniProt (O44729) Pfam (PF00400) | Caenorhabditis elegans | |
| 27 | AA (X) | Replication stress response regulator SDE2 | polymer | 500 | 57466.1 | 1 | UniProt (G5EC45) Pfam (PF22782) Pfam (PF13297) | Caenorhabditis elegans | |
| 28 | BA (Z) | Coiled-coil domain-containing protein 12 | polymer | 69 | 8135.5 | 1 | UniProt (Q95XJ1) Pfam (PF08315) | Caenorhabditis elegans | |
| 29 | CA, JA (a, h) | Small nuclear ribonucleoprotein Sm D3 | polymer | 136 | 14836.2 | 2 | UniProt (Q17348) Pfam (PF01423) | Caenorhabditis elegans | Sm-D3,snRNP core protein D3 |
| 30 | DA, KA (b, i) | Probable small nuclear ribonucleoprotein-associated protein B | polymer | 160 | 16768.6 | 2 | UniProt (P91918) Pfam (PF01423) | Caenorhabditis elegans | snRNP-B,Sm protein B,Sm-B,SmB |
| 31 | EA, LA (c, j) | Small nuclear ribonucleoprotein Sm D1 | polymer | 127 | 13724.1 | 2 | UniProt (E3LR34) Pfam (PF01423) UniProt (by SIFTS) (Q10013) | Caenorhabditis elegans | snRNP core protein D1 |
| 32 | FA, MA (d, k) | Probable small nuclear ribonucleoprotein Sm D2 | polymer | 118 | 13291.5 | 2 | UniProt (Q18786) Pfam (PF01423) | Caenorhabditis elegans | Sm-D2,snRNP core protein D2 |
| 33 | GA, NA (e, l) | Probable small nuclear ribonucleoprotein E | polymer | 90 | 10625.3 | 2 | UniProt (Q9XTU6) Pfam (PF01423) | Caenorhabditis elegans | snRNP-E,Sm protein E,Sm-E,SmE |
| 34 | HA, OA (f, m) | Probable small nuclear ribonucleoprotein F | polymer | 85 | 9256.5 | 2 | UniProt (P34659) Pfam (PF01423) | Caenorhabditis elegans | snRNP-F,Sm protein F,Sm-F,SmF |
| 35 | IA, PA (g, n) | Probable small nuclear ribonucleoprotein G | polymer | 77 | 8756.2 | 2 | UniProt (Q9N4G9) Pfam (PF01423) | Caenorhabditis elegans | snRNP-G,Sm protein G,Sm-G,SmG |
| 36 | QA (o) | Probable U2 small nuclear ribonucleoprotein A' | polymer | 253 | 28905.9 | 1 | UniProt (Q9BLB6) Pfam (PF12799) | Caenorhabditis elegans | U2 snRNP A',Masculinization of germline protein 2,Spliceosome-associated protein mog-2 |
| 37 | RA (p) | RRM domain-containing protein | polymer | 217 | 24881.3 | 1 | UniProt (Q21323) Pfam (PF00076) | Caenorhabditis elegans | |
| 38 | SA, TA, UA, VA (q, r, s, t) | Pre-mRNA-processing factor 19 | polymer | 492 | 53272.6 | 4 | UniProt (Q10051) Pfam (PF04564) Pfam (PF08606) Pfam (PF00400) | Caenorhabditis elegans | PRP19/PSO4 homolog,RING-type E3 ubiquitin transferase PRP19 |
| 39 | WA (y) | Peptidyl-prolyl cis-trans isomerase E | polymer | 79 | 8825.0 | 1 | UniProt (Q9U2S6) Pfam (PF00076) | Caenorhabditis elegans | PPIase E |
| 40 | AB, BB, CB, FB, XA... (6, C) | MAGNESIUM ION | non-polymer | 24.3 | 7 | Chemie (MG) PubChem (888) | |||
| 41 | DB, GB (A, J) | INOSITOL HEXAKISPHOSPHATE | non-polymer | 660.0 | 2 | Chemie (IHP) | |||
| 42 | EB (C) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (GTP) PubChem (177679032) PubChem (135400627) PubChem (135487750) PubChem (136088935) PubChem (136803486) PubChem (135398633) PubChem (135544356) PubChem (135547949) PubChem (135600366) PubChem (135749822) PubChem (136005188) PubChem (136073923) PubChem (136240914) PubChem (136664747) PubChem (136772743) PubChem (136772744) PubChem (136803487) PubChem (137286749) PubChem (164715984) PubChem (171699466) | |||
| 43 | HB, IB, JB, KB, LB... (L2, N, O) | ZINC ION | non-polymer | 65.4 | 7 | Chemie (ZN) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 49 |
| Total formula weight | 2287213.3 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 2471.2 | |
| All* | Total formula weight | 2289684.6 |
