8RNS
Human Carbonic Anhydrase XII mimic in complex with biguanide derivative inhibitor 1-carbamimidamido-N-[(4 sulfamoylphenyl)methyl]methanimidamide
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Carbonic anhydrase 2 | polymer | 260 | 29233.9 | 1 | UniProt (P00918) Pfam (PF00194) | Homo sapiens (human) | Carbonate dehydratase II,Carbonic anhydrase C,CAC,Carbonic anhydrase II,CA-II,Cyanamide hydratase CA2 |
| 2 | B (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | C (A) | 1-carbamimidoyl-3-[(4-sulfamoylphenyl)methyl]guanidine | non-polymer | 270.3 | 1 | Chemie (A1H15) | |||
| 4 | D (A) | water | water | 18.0 | 240 | Chemie (HOH) |
Sequence modifications
A: 1 - 260 (UniProt: P00918)
| PDB | External Database | Details |
|---|---|---|
| Ser 65 | Ala 65 | engineered mutation |
| Lys 67 | Asn 67 | engineered mutation |
| Asn 69 | Glu 69 | engineered mutation |
| Thr 91 | Ile 91 | engineered mutation |
| Ala 130 | Phe 130 | engineered mutation |
| Ser 131 | Gly 131 | engineered mutation |
| Ser 134 | Val 134 | engineered mutation |
| Asn 203 | Leu 203 | engineered mutation |
| Thr 205 | Cys 205 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 29233.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 335.7 | |
| All* | Total formula weight | 29569.6 |
