8RMB

Erk2 MAP kinase (R65S+T188D) double mutant

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Mitogen-activated protein kinase 1	polymer	365	42174.4	1	UniProt (P63086) Pfam (PF00069)	Rattus norvegicus (Norway rat)	MAP kinase 1,MAPK 1,ERT1,Extracellular signal-regulated kinase 2,ERK-2,MAP kinase isoform p42,p42-MAPK,Mitogen-activated protein kinase 2,MAP kinase 2,MAPK 2
2	B (A)	water	water		18.0	180	Chemie (HOH)

Sequence modifications

A: 1 - 358 (UniProt: P63086)

PDB	External Database	Details
Ala -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
Ser 65	Arg 65	engineered mutation
Asp 188	Thr 188	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	42174.4
All*	Total formula weight	42174.4

*Water molecules are not included.