8RM0
Cryo-EM structure of a Foamy Virus fusion glycoprotein stabilized in the prefusion conformation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Envelope glycoprotein gp130 | polymer | 890 | 101784.5 | 3 | UniProt (K7YEW5) Pfam (PF03408) | Simian foamy virus | Env polyprotein |
| 2 | D, E, G, H, I... (D, E, G, H, I...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 9 | In PDB GlyTouCan (G42666HT) | |||
| 3 | F, J, N (F, J, N) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 3 | In PDB GlyTouCan (G22768VO) | |||
| 4 | AA, BA, CA, DA, P... (C, A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 15 | Chemie (NAG) |
Sequence modifications
A, B, C: 91 - 556 (UniProt: K7YEW5)
A, B, C: 556 - 907 (UniProt: K7YEW5)
| PDB | External Database | Details |
|---|---|---|
| Ala 126 | Arg 126 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 556 | - | linker |
| Gly 556 | - | linker |
| Gly 556 | - | linker |
| Gly 556 | - | linker |
| Ser 556 | - | linker |
| Gly 556 | - | linker |
| Gly 556 | - | linker |
| Gly 556 | - | linker |
| Gly 556 | - | linker |
| Ser 556 | - | linker |
| Pro 630 | Glu 630 | engineered mutation |
| Ser 908 | - | expression tag |
| Ala 909 | - | expression tag |
| Ile 910 | - | expression tag |
| Gly 911 | - | expression tag |
| Gly 912 | - | expression tag |
| Tyr 913 | - | expression tag |
| Ile 914 | - | expression tag |
| Pro 915 | - | expression tag |
| Glu 916 | - | expression tag |
| Ala 917 | - | expression tag |
| Pro 918 | - | expression tag |
| Arg 919 | - | expression tag |
| Asp 920 | - | expression tag |
| Gly 921 | - | expression tag |
| Gln 922 | - | expression tag |
| Ala 923 | - | expression tag |
| Tyr 924 | - | expression tag |
| Val 925 | - | expression tag |
| Arg 926 | - | expression tag |
| Lys 927 | - | expression tag |
| Asp 928 | - | expression tag |
| Gly 929 | - | expression tag |
| Glu 930 | - | expression tag |
| Trp 931 | - | expression tag |
| Val 932 | - | expression tag |
| Leu 933 | - | expression tag |
| Leu 934 | - | expression tag |
| Ser 935 | - | expression tag |
| Thr 936 | - | expression tag |
| Phe 937 | - | expression tag |
| Leu 938 | - | expression tag |
| Gly 939 | - | expression tag |
| Asp 940 | - | expression tag |
| Asp 941 | - | expression tag |
| Asp 942 | - | expression tag |
| Asp 943 | - | expression tag |
| Lys 944 | - | expression tag |
| Ala 945 | - | expression tag |
| Gly 946 | - | expression tag |
| Trp 947 | - | expression tag |
| Ser 948 | - | expression tag |
| His 949 | - | expression tag |
| Pro 950 | - | expression tag |
| Gln 951 | - | expression tag |
| Phe 952 | - | expression tag |
| Glu 953 | - | expression tag |
| Lys 954 | - | expression tag |
| Gly 955 | - | expression tag |
| Gly 956 | - | expression tag |
| Gly 957 | - | expression tag |
| Ser 958 | - | expression tag |
| Gly 959 | - | expression tag |
| Gly 960 | - | expression tag |
| Gly 961 | - | expression tag |
| Ser 962 | - | expression tag |
| Gly 963 | - | expression tag |
| Gly 964 | - | expression tag |
| Gly 965 | - | expression tag |
| Ser 966 | - | expression tag |
| Trp 967 | - | expression tag |
| Ser 968 | - | expression tag |
| His 969 | - | expression tag |
| Pro 970 | - | expression tag |
| Gln 971 | - | expression tag |
| Phe 972 | - | expression tag |
| Glu 973 | - | expression tag |
| Lys 974 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 305353.5 | |
| Branched | Number of molecules | 12 |
| Total formula weight | 6552.1 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 3318.1 | |
| All* | Total formula weight | 315223.7 |
