8RLU

TCR in complex with HLA-E*01:03 bound to HBV envelope 371-379 S3N peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, F (A, F)	HLA class I histocompatibility antigen, alpha chain E	polymer	276	31824.0	2	UniProt (P13747) Pfam (PF00129) Pfam (PF07654)	Homo sapiens (human)	MHC class I antigen E
2	B, G (B, G)	Beta-2-microglobulin	polymer	100	11879.4	2	UniProt (P61769) Pfam (PF07654)	Homo sapiens (human)
3	C, H (C, H)	Large envelope protein	polymer	9	1039.3	2	UniProt (Q67953)	Hepatitis B virus	L glycoprotein,L-HBsAg,LHB,Large S protein,Large surface protein,Major surface antigen
4	D, I (D, I)	T cell receptor alpha variable 12-2,T cell receptor alpha chain MC.7.G5	polymer	199	21944.4	2	UniProt (A0A075B6T6) UniProt (P0DTU3) Pfam (PF07686) Pfam (PF09291)	Homo sapiens (human)	MC.7.G5 TRA,TR alpha chain TRAV38-2DV8*01J31*01C*01
5	E, J (E, J)	T cell receptor beta variable 6-5,T cell receptor beta chain MC.7.G5	polymer	243	27436.6	2	UniProt (A0A0K0K1A5) UniProt (P0DTU4) Pfam (PF07686) Pfam (PF07654)	Homo sapiens (human)	TR beta chain TRBV25-1*01J2S3*01C2*01,MC.7.G5 TRB
6	K, L, M, N, O... (A, B, C, D, E...)	water	water		18.0	237	Chemie (HOH)

Sequence modifications

B, G: 1 - 99 (UniProt: P61769)

PDB	External Database	Details
Met 0	-	initiating methionine

C, H: 1 - 9 (UniProt: Q67953)

PDB	External Database	Details
Asn 3	Ser 429	engineered mutation

D, I: 2 - 91 (UniProt: A0A075B6T6)

PDB	External Database	Details
Met 0	-	initiating methionine
Ala 1	-	expression tag
Val 31	Gln 52	variant
Ser 49	Phe 70	variant
Leu 52	Ser 73	variant
Leu 55	Asp 76	variant
Gly 92	-	variant
Asn 93	-	variant
His 94	-	variant
Asn 95	-	variant
Thr 96	-	variant
Gly 97	-	variant
Asn 98	-	variant
Met 99	-	variant
Leu 100	-	variant
Thr 101	-	variant
Phe 102	-	variant
Gly 103	-	variant
Gly 104	-	variant
Gly 105	-	variant
Thr 106	-	variant
Arg 107	-	variant
Leu 108	-	variant
Met 109	-	variant

D, I: 110 - 198 (UniProt: P0DTU3)

PDB	External Database	Details
His 113	Asn 135	variant
Cys 160	Thr 182	variant

E, J: 1 - 93 (UniProt: A0A0K0K1A5)

PDB	External Database	Details
Met 0	-	initiating methionine
Tyr 29	His 48	variant
Ser 51	Gly 70	variant
Leu 54	Ile 73	variant
His 94	-	variant
Arg 95	-	variant
Asn 96	-	variant
Arg 97	-	variant
Leu 98	-	variant
Thr 99	-	variant
Glu 100	-	variant
Ala 101	-	variant
Phe 102	-	variant

E, J: 103 - 242 (UniProt: P0DTU4)

PDB	External Database	Details
Gln 105	Pro 129	variant
Val 112	Leu 136	variant
Cys 169	Ser 193	variant
Ala 187	Cys 211	variant
Asp 201	Asn 225	variant

Contents of the asymmetric unit

Polymers	Number of chains	10
	Total formula weight	188247.2
All*	Total formula weight	188247.2

*Water molecules are not included.