8RJJ

HCV E1/E2 homodimer complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (C, A)	Genome polyprotein	polymer	191	20681.8	2	UniProt (Q81424)	Hepacivirus hominis
2	B, D (D, B)	HCV S52 E2	polymer	369	41050.8	2	UniProt (A9YFN8)	Hepacivirus hominis
3	E, F, G, H, I... (L, E, F, G, H...)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	10	In PDB GlyTouCan (G42666HT)
4	O, P, Q, R, S... (O, P, Q, R, S...)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	8	In PDB GlyTouCan (G15407YE)
5	W, X (D, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)

Sequence modifications

C, A: 193 - 383 (UniProt: Q81424)

PDB	External Database	Details
Asp 233	Gly 42	conflict
Thr 237	Met 46	conflict
Val 355	Ile 164	conflict
Ile 359	Leu 168	conflict
Phe 362	Tyr 171	conflict
Val 365	Gln 174	conflict
Leu 372	Ala 181	conflict
Val 373	Ile 182	conflict
Leu 375	Met 184	conflict
Leu 376	Ile 185	conflict
Leu 377	Met 186	conflict
Ala 379	Ser 188	conflict

D, B: 384 - 752 (UniProt: A9YFN8)

PDB	External Database	Details
Gly 576	Glu 576	conflict
Asn 578	Asp 578	conflict
Gly 580	Glu 580	conflict
Leu 694	Gly 694	conflict
Gly 695	Leu 695	conflict
Tyr 724	Phe 724	conflict
Val 726	Ile 726	conflict
Leu 728	Val 728	conflict
Ser 739	Val 739	conflict
Cys 740	Ala 740	conflict
Met 743	Leu 743	conflict
Leu 746	Met 746	conflict
Ile 747	Val 747	conflict

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	123465.2
Branched	Number of molecules	18
	Total formula weight	8936.3
Non-Polymers*	Number of molecules	2
	Total formula weight	442.4
All*	Total formula weight	132844.0

*Water molecules are not included.