8RI2
Crystal structure of NLRP3 in complex with inhibitor NP3-562
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | NACHT, LRR and PYD domains-containing protein 3 | polymer | 550 | 64156.3 | 1 | UniProt (Q96P20) Pfam (PF14484) Pfam (PF05729) Pfam (PF17779) Pfam (PF17776) In PDB | Homo sapiens (human) | Angiotensin/vasopressin receptor AII/AVP-like,Caterpiller protein 1.1,CLR1.1,Cold-induced autoinflammatory syndrome 1 protein,Cryopyrin,PYRIN-containing APAF1-like protein 1 |
| 2 | A | 2-[4-chloranyl-9-oxidanylidene-12-(2-oxidanylpropan-2-yl)-5-thia-1,10,11-triazatricyclo[6.4.0.0^{2,6}]dodeca-2(6),3,7,11-tetraen-10-yl]-~{N}-[(3~{R})-1-methylpiperidin-3-yl]ethanamide | non-polymer | 437.9 | 1 | Chemie (A1H02) | |||
| 3 | A | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 4 | water | water | 18.0 | 80 | Chemie (HOH) |
Sequence modifications
A: 131 - 679 (UniProt: Q96P20)
| PDB | External Database | Details |
|---|---|---|
| Gly 130 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 64156.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 865.1 | |
| All* | Total formula weight | 65021.4 |
