8REX
CryoEM structure of mouse GARP-lTGFbeta1 in complex with a Fab fragment derived from an activating antibody.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Transforming growth factor beta-1 proprotein | polymer | 390 | 44369.9 | 4 | UniProt (P04202) | Mus musculus (house mouse) | |
| 2 | E (E) | Transforming growth factor beta activator LRRC32 | polymer | 675 | 73699.9 | 1 | UniProt (G3XA59) | Mus musculus (house mouse) | Garpin,Glycoprotein A repetitions predominant,GARP,Leucine-rich repeat-containing protein 32 |
| 3 | F, I (F, I) | mFab LMT-12, Light Chain | polymer | 236 | 24713.6 | 2 | Mus musculus (house mouse) | ||
| 4 | G, H (G, H) | mFab LMT-12, Heavy Chain | polymer | 247 | 26143.4 | 2 | Mus musculus (house mouse) | ||
| 5 | J, K, L (J, K, L) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
| 6 | M, N (A, E) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) |
Sequence modifications
E: 1 - 629 (UniProt: G3XA59)
| PDB | External Database | Details |
|---|---|---|
| Glu 630 | - | expression tag |
| Ala 631 | - | expression tag |
| Ala 632 | - | expression tag |
| Ala 633 | - | expression tag |
| Glu 634 | - | expression tag |
| Asn 635 | - | expression tag |
| Leu 636 | - | expression tag |
| Tyr 637 | - | expression tag |
| Phe 638 | - | expression tag |
| Gln 639 | - | expression tag |
| Gly 640 | - | expression tag |
| Ala 641 | - | expression tag |
| Ala 642 | - | expression tag |
| Trp 643 | - | expression tag |
| Ser 644 | - | expression tag |
| His 645 | - | expression tag |
| Pro 646 | - | expression tag |
| Gln 647 | - | expression tag |
| Phe 648 | - | expression tag |
| Glu 649 | - | expression tag |
| Lys 650 | - | expression tag |
| Gly 651 | - | expression tag |
| Ala 652 | - | expression tag |
| Ala 653 | - | expression tag |
| Trp 654 | - | expression tag |
| Ser 655 | - | expression tag |
| His 656 | - | expression tag |
| Pro 657 | - | expression tag |
| Gln 658 | - | expression tag |
| Phe 659 | - | expression tag |
| Glu 660 | - | expression tag |
| Lys 661 | - | expression tag |
| Gly 662 | - | expression tag |
| Ala 663 | - | expression tag |
| Ala 664 | - | expression tag |
| Trp 665 | - | expression tag |
| Ser 666 | - | expression tag |
| His 667 | - | expression tag |
| Pro 668 | - | expression tag |
| Gln 669 | - | expression tag |
| Phe 670 | - | expression tag |
| Glu 671 | - | expression tag |
| Lys 672 | - | expression tag |
| Gly 673 | - | expression tag |
| Ala 674 | - | expression tag |
| Ala 675 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 9 |
| Total formula weight | 352893.5 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 1273.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 442.4 | |
| All* | Total formula weight | 354609.1 |
