8RAX
The crystal structure of DNA-bound human MutSbeta (MSH2_G674D/MSH3) in the canonical mismatch bound conformation, nucleotide free
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DNA mismatch repair protein Msh2 | polymer | 934 | 104919.9 | 1 | UniProt (P43246) | Homo sapiens (human) | |
| 2 | B (B) | DNA mismatch repair protein Msh3 | polymer | 918 | 104289.7 | 1 | UniProt (P20585) | Homo sapiens (human) | |
| 3 | C (C) | DNA (5'-D(P*AP*TP*CP*TP*GP*AP*AP*GP*CP*CP*GP*AP*TP*CP*GP*AP*TP*G)-3') | polymer | 24 | 7345.7 | 1 | synthetic construct | ||
| 4 | D (D) | DNA (5'-D(*TP*CP*AP*TP*CP*GP*AP*TP*CP*GP*CP*AP*GP*CP*TP*TP*CP*AP*GP*AP*TP*A)-3') | polymer | 24 | 7369.8 | 1 | synthetic construct | ||
| 5 | E, F, G, H (A, B, C, D) | water | water | 18.0 | 35 | Chemie (HOH) |
Sequence modifications
A: 1 - 934 (UniProt: P43246)
B: 219 - 1134 (UniProt: P20585)
| PDB | External Database | Details |
|---|---|---|
| Asp 674 | Gly 674 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 217 | - | expression tag |
| Pro 218 | - | expression tag |
| Arg 949 | Gln 949 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 223925.1 | |
| All* | Total formula weight | 223925.1 |
