8R7G
Crystal structure of the kinase domain of ACVR1 (ALK2) with M4K2234
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Activin receptor type I | polymer | 301 | 34537.6 | 4 | UniProt (Q04771) Pfam (PF07714) | Homo sapiens (human) | |
| 2 | E, F, G, H (A, B, C, D) | 2-fluoranyl-6-methoxy-4-[4-methyl-5-[4-(4-propan-2-ylpiperazin-1-yl)phenyl]pyridin-3-yl]benzamide | non-polymer | 462.6 | 4 | Chemie (YEE) | |||
| 3 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 97 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 201 - 499 (UniProt: Q04771)
| PDB | External Database | Details |
|---|---|---|
| Ser 199 | - | expression tag |
| Met 200 | - | expression tag |
| Asp 207 | Gln 207 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 138150.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1850.2 | |
| All* | Total formula weight | 140000.8 |
