8R6O
Tubulin-4AZA2996 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Detyrosinated tubulin alpha-1B chain | polymer | 451 | 50204.4 | 2 | UniProt (P81947) Pfam (PF00091) Pfam (PF03953) | Bos taurus (cattle) | |
| 2 | B, D (B, D) | Tubulin beta-2B chain | polymer | 445 | 49999.9 | 2 | UniProt (Q6B856) Pfam (PF00091) Pfam (PF03953) | Bos taurus (cattle) | |
| 3 | E (E) | Stathmin-4 | polymer | 143 | 16844.2 | 1 | UniProt (P63043) Pfam (PF00836) | Rattus norvegicus (Norway rat) | Stathmin-like protein B3,RB3 |
| 4 | F (F) | Tubulin tyrosine ligase | polymer | 384 | 44378.5 | 1 | UniProt (A0A8V0Z8P0) Pfam (PF03133) | Gallus gallus (chicken) | |
| 5 | G, O (A, C) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 2 | Chemie (GTP) PubChem (177679032) PubChem (135400627) PubChem (135487750) PubChem (136088935) PubChem (136803486) PubChem (135398633) PubChem (135544356) PubChem (135547949) PubChem (135600366) PubChem (135749822) PubChem (136005188) PubChem (136073923) PubChem (136240914) PubChem (136664747) PubChem (136772743) PubChem (136772744) PubChem (136803487) PubChem (137286749) PubChem (164715984) PubChem (171699466) | |||
| 6 | H, K, P, S, V (A, B, C, D, F) | MAGNESIUM ION | non-polymer | 24.3 | 5 | Chemie (MG) PubChem (888) | |||
| 7 | I, N, Q (A, B, C) | CALCIUM ION | non-polymer | 40.1 | 3 | Chemie (CA) PubChem (271) | |||
| 8 | J, R (B, D) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 2 | Chemie (GDP) PubChem (136073927) PubChem (135398619) PubChem (135402030) PubChem (135431654) PubChem (135566337) PubChem (135760556) PubChem (136026707) PubChem (136053418) PubChem (136663964) PubChem (136664748) PubChem (136759848) PubChem (136759849) PubChem (136759850) PubChem (136836636) PubChem (136847074) PubChem (172898537) | |||
| 9 | L, T (B, D) | N6-(4-methylpyridin-2-yl)-N2-(2-morpholinoethyl)-3-nitropyridine-2,6-diamine | non-polymer | 358.4 | 2 | Chemie (RME) PubChem (155804527) | |||
| 10 | M (B) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) PubChem (4478249) | |||
| 11 | U (F) | PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER | non-polymer | 505.2 | 1 | Chemie (ACP) PubChem (4799) PubChem (46936826) PubChem (91532) PubChem (91885473) PubChem (134943439) PubChem (157749842) PubChem (157749839) | |||
| 12 | AA, BA, W, X, Y... (E, F, A, B, C...) | water | water | 18.0 | 342 | Chemie (HOH) |
Sequence modifications
E: 5 - 145 (UniProt: P63043)
F: 1 - 378 (UniProt: A0A8V0Z8P0)
| PDB | External Database | Details |
|---|---|---|
| Met 3 | - | initiating methionine |
| Ala 4 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| - | Ala 53 | deletion |
| - | Glu 54 | deletion |
| - | Met 55 | deletion |
| - | Gln 56 | deletion |
| - | Gln 57 | deletion |
| - | Gln 58 | deletion |
| - | Leu 59 | deletion |
| - | Leu 60 | deletion |
| - | Glu 61 | deletion |
| - | Gly 62 | deletion |
| - | Asp 63 | deletion |
| - | Gln 64 | deletion |
| - | Thr 65 | deletion |
| - | Leu 66 | deletion |
| - | Val 67 | deletion |
| - | Leu 68 | deletion |
| - | Ala 69 | deletion |
| - | Ser 70 | deletion |
| - | Ser 71 | deletion |
| - | Thr 72 | deletion |
| - | His 73 | deletion |
| - | Pro 74 | deletion |
| - | Glu 75 | deletion |
| - | Ser 76 | deletion |
| - | Val 77 | deletion |
| - | Asp 78 | deletion |
| - | Ser 79 | deletion |
| - | Asp 80 | deletion |
| - | Lys 81 | deletion |
| - | Asn 82 | deletion |
| - | His 83 | deletion |
| - | Gly 84 | deletion |
| - | Phe 85 | deletion |
| His 379 | - | expression tag |
| His 380 | - | expression tag |
| His 381 | - | expression tag |
| His 382 | - | expression tag |
| His 383 | - | expression tag |
| His 384 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 261631.3 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 3591.8 | |
| All* | Total formula weight | 265223.1 |
