8R4O
Salt inducible kinase 3 in complex with inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G, I... (A, C, E, G, I...) | Serine/threonine-protein kinase SIK3 | polymer | 328 | 37888.9 | 6 | UniProt (Q9Y2K2) Pfam (PF00069) | Homo sapiens (human) | |
| 2 | B, D, F, H, J... (B, D, F, H, J...) | scFvH1 | polymer | 273 | 28384.0 | 6 | Homo sapiens | ||
| 3 | M, O, R, S, U... (A, C, E, G, I...) | 2-[bis(fluoranyl)methoxy]-4-[6-(2-cyanopropan-2-yl)pyrazolo[1,5-a]pyridin-3-yl]-~{N}-[(1~{R},2~{S})-2-fluoranylcyclopropyl]-6-methoxy-benzamide | non-polymer | 458.4 | 6 | Chemie (XVI) | |||
| 4 | N, P, Q, T, V... (A, C, G, I, K) | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
| 5 | AA, BA, CA, DA, EA... (C, D, E, F, G...) | water | water | 18.0 | 120 | Chemie (HOH) |
Sequence modifications
A, C, E, G, I, K: 59 - 385 (UniProt: Q9Y2K2)
| PDB | External Database | Details |
|---|---|---|
| Ser 58 | - | expression tag |
| Ser 121 | Cys 121 | engineered mutation |
| Ser 181 | Cys 181 | engineered mutation |
| Ser 333 | Cys 333 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 397637.3 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 3327.0 | |
| All* | Total formula weight | 400964.3 |
