8R2H

Cryo-EM structure of 1-deoxy-D-xylulose 5-phosphate synthase (DXPS) from Plasmodium falciparum

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	1-deoxy-D-xylulose-5-phosphate synthase	polymer	916	105953.6	2	UniProt (O96694) Pfam (PF13292) Pfam (PF02779) Pfam (PF02780) In PDB	Plasmodium falciparum (malaria parasite P. falciparum)
2	A, B	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
3	A, B	THIAMINE DIPHOSPHATE	non-polymer		425.3	2	Chemie (TPP)

Sequence modifications

A, B: 311 - 1205 (UniProt: O96694)

PDB	External Database	Details
Met 290	-	initiating methionine
Gly 291	-	expression tag
Ser 292	-	expression tag
Ser 293	-	expression tag
His 294	-	expression tag
His 295	-	expression tag
His 296	-	expression tag
His 297	-	expression tag
His 298	-	expression tag
His 299	-	expression tag
Ser 300	-	expression tag
Ser 301	-	expression tag
Gly 302	-	expression tag
Leu 303	-	expression tag
Val 304	-	expression tag
Pro 305	-	expression tag
Arg 306	-	expression tag
Gly 307	-	expression tag
Ser 308	-	expression tag
His 309	-	expression tag
Met 310	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	211907.2
Non-Polymers*	Number of molecules	4
	Total formula weight	899.2
All*	Total formula weight	212806.5

*Water molecules are not included.