8R2D

Integrator cleavage module assembly intermediate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	BRCA1-associated ATM activator 1	polymer	827	88766.3	1	UniProt (Q6PJG6) Pfam (PF02985)	Homo sapiens (human)
2	B (B)	Integrator complex subunit 9	polymer	658	73891.2	1	UniProt (Q9NV88) Pfam (PF16661) Pfam (PF10996) Pfam (PF21382)	Homo sapiens (human)	Int9,Protein related to CPSF subunits of 74 kDa,RC-74
3	C (C)	Integrator complex subunit 11	polymer	612	68997.9	1	UniProt (Q5TA45) Pfam (PF16661) Pfam (PF10996) Pfam (PF07521) Pfam (PF21386)	Homo sapiens (human)
4	D (D)	Integrator complex subunit 4	polymer	973	109271.8	1	UniProt (Q96HW7) Pfam (PF13646) Pfam (PF24493) Pfam (PF25458) Pfam (PF20168)	Homo sapiens (human)
5	E, F (C)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)

Sequence modifications

A: 1 - 821 (UniProt: Q6PJG6)

PDB	External Database	Details
Gly -5	-	expression tag
Pro -4	-	expression tag
Ser -3	-	expression tag
Gln -2	-	expression tag
Ser -1	-	expression tag
Asn 0	-	expression tag

C: 1 - 600 (UniProt: Q5TA45)

PDB	External Database	Details
Gly -11	-	expression tag
Pro -10	-	expression tag
Ser -9	-	expression tag
Asp -8	-	expression tag
Pro -7	-	expression tag
Gly -6	-	expression tag
Pro -5	-	expression tag
Lys -4	-	expression tag
Arg -3	-	expression tag
Ala -2	-	expression tag
Glu -1	-	expression tag
Phe 0	-	expression tag

D: 1 - 963 (UniProt: Q96HW7)

PDB	External Database	Details
Gly -9	-	expression tag
Pro -8	-	expression tag
Ser -7	-	expression tag
Asp -6	-	expression tag
Pro -5	-	expression tag
Gly -4	-	expression tag
Pro -3	-	expression tag
Lys -2	-	expression tag
Arg -1	-	expression tag
Ala 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	340927.3
Non-Polymers*	Number of molecules	2
	Total formula weight	130.8
All*	Total formula weight	341058.1

*Water molecules are not included.