8R26
SARS-CoV-2 Mpro (Omicron,P132H) in complex with alpha-ketoamide 13b-K at pH 8.5
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, D, C) | 3C-like proteinase nsp5 | polymer | 306 | 33866.6 | 4 | UniProt (P0DTC1) Pfam (PF05409) | Severe acute respiratory syndrome coronavirus 2 | 3CL-PRO,3CLp,Main protease,Mpro,Non-structural protein 5,nsp5,SARS coronavirus main proteinase |
| 2 | E, G, H, J (A, B, D, C) | ~{tert}-butyl ~{N}-[1-[(2~{S})-3-cyclopropyl-1-oxidanylidene-1-[[(2~{S},3~{R})-3-oxidanyl-4-oxidanylidene-1-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]-4-[(phenylmethyl)amino]butan-2-yl]amino]propan-2-yl]-2-oxidanylidene-pyridin-3-yl]carbamate | non-polymer | 595.7 | 4 | Chemie (O6K) | |||
| 3 | F, I, K (A, D, C) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
| 4 | L, M, N, O (A, B, D, C) | water | water | 18.0 | 365 | Chemie (HOH) |
Sequence modifications
A, B, D, C: 1 - 306 (UniProt: P0DTC1)
| PDB | External Database | Details |
|---|---|---|
| His 132 | Pro 3395 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 135466.3 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 2489.1 | |
| All* | Total formula weight | 137955.4 |
