8R22

INTS9-INTS11-BRAT1-WDR73 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	BRCA1-associated ATM activator 1	polymer	827	88766.3	1	UniProt (Q6PJG6) In PDB	Homo sapiens (human)
2	B	Integrator complex subunit 9	polymer	658	73891.2	1	UniProt (Q9NV88) In PDB	Homo sapiens (human)	Int9,Protein related to CPSF subunits of 74 kDa,RC-74
3	C	Integrator complex subunit 11	polymer	612	68997.9	1	UniProt (Q5TA45) In PDB	Homo sapiens (human)
4	D	WD repeat-containing protein 73	polymer	385	42391.6	1	UniProt (Q6P4I2) In PDB	Homo sapiens (human)
5	C	ZINC ION	non-polymer		65.4	1	Chemie (ZN)

Sequence modifications

A: 1 - 821 (UniProt: Q6PJG6)

PDB	External Database	Details
Gly -5	-	expression tag
Pro -4	-	expression tag
Ser -3	-	expression tag
Gln -2	-	expression tag
Ser -1	-	expression tag
Asn 0	-	expression tag

C: 1 - 600 (UniProt: Q5TA45)

PDB	External Database	Details
Gly -11	-	expression tag
Pro -10	-	expression tag
Ser -9	-	expression tag
Asp -8	-	expression tag
Pro -7	-	expression tag
Gly -6	-	expression tag
Pro -5	-	expression tag
Lys -4	-	expression tag
Arg -3	-	expression tag
Ala -2	-	expression tag
Glu -1	-	expression tag
Phe 0	-	expression tag

D: 1 - 378 (UniProt: Q6P4I2)

PDB	External Database	Details
Gly -6	-	expression tag
Pro -5	-	expression tag
Ser -4	-	expression tag
Gln -3	-	expression tag
Ser -2	-	expression tag
Asn -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	274047.0
Non-Polymers*	Number of molecules	1
	Total formula weight	65.4
All*	Total formula weight	274112.4

*Water molecules are not included.