8QZM

Structure of DNMT3A1 UDR region bound to H2AK119ub nucleosome

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, E (A, E)	Histone H3 (Fragment)	polymer	135	15257.8	2	UniProt (A0A7K7T3V7) Pfam (PF00125)	Homo sapiens (human)
2	B, F (B, F)	Histone H4	polymer	102	11263.2	2	UniProt (P62805) Pfam (PF15511)	Homo sapiens (human)
3	C, G (C, G)	Histone H2A type 1	polymer	129	13964.3	2	UniProt (P0C0S8) Pfam (PF00125) Pfam (PF16211)	Homo sapiens (human)	H2A.1,Histone H2A/ptl
4	D, H (D, H)	Histone H2B type 1-C/E/F/G/I	polymer	125	13806.0	2	UniProt (P62807) Pfam (PF00125)	Homo sapiens (human)	Histone H2B.1 A,Histone H2B.a,H2B/a,Histone H2B.g,H2B/g,Histone H2B.h,H2B/h,Histone H2B.k,H2B/k,Histone H2B.l,H2B/l
5	I (I)	DNA (145-MER)	polymer	195	60642.6	1		synthetic construct
6	J (J)	DNA (145-MER)	polymer	195	59771.0	1		synthetic construct
7	K (K)	DNA (cytosine-5)-methyltransferase 3A	polymer	915	102269.7	1	UniProt (Q9Y6K1) Pfam (PF00145) Pfam (PF22855) Pfam (PF00855) Pfam (PF17980) Pfam (PF21255)	Homo sapiens (human)

Sequence modifications

A, E: 1 - 135 (UniProt: A0A7K7T3V7)

PDB	External Database	Details
Ala 110	Cys 111	conflict

C, G: 1 - 129 (UniProt: P0C0S8)

PDB	External Database	Details
Cys 119	Lys 120	engineered mutation

K: 1 - 912 (UniProt: Q9Y6K1)

PDB	External Database	Details
Ser -2	-	expression tag
Asn -1	-	expression tag
Ala 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	11
	Total formula weight	331266.1
All*	Total formula weight	331266.1

*Water molecules are not included.