8QZ4
Crystal structure of human two pore domain potassium ion channel TREK-2 (K2P10.1) in complex with an activatory nanobody (Nb76)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Potassium channel subfamily K member 10 | polymer | 282 | 31060.1 | 2 | UniProt (P57789) Pfam (PF07885) | Homo sapiens (human) | Outward rectifying potassium channel protein TREK-2,TREK-2 K(+) channel subunit |
| 2 | C, D (C, D) | Nanobody 76 | polymer | 123 | 13648.2 | 2 | Lama glama | ||
| 3 | E, F, J, K (A, B) | BARIUM ION | non-polymer | 137.3 | 4 | Chemie (BA) PubChem (104810) | |||
| 4 | G, H, I, L (A, B) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 4 | Chemie (Y01) PubChem (65082) PubChem (363416) PubChem (500055) PubChem (13301926) PubChem (13301927) PubChem (16219150) PubChem (22210610) PubChem (45489984) PubChem (57163942) PubChem (89891013) PubChem (99567468) PubChem (124427194) PubChem (124897021) PubChem (124897020) PubChem (10005657) PubChem (130340716) PubChem (11969853) PubChem (137392566) PubChem (137496323) PubChem (155804219) PubChem (169132514) PubChem (60078761) PubChem (73440805) PubChem (99567469) PubChem (124301053) PubChem (124302591) PubChem (124303794) PubChem (124421343) PubChem (124427195) PubChem (124914595) PubChem (124914596) PubChem (131705526) PubChem (137332121) PubChem (137496357) PubChem (146157332) PubChem (154929912) PubChem (155199678) PubChem (156327905) PubChem (156426247) PubChem (156516588) PubChem (166979870) PubChem (167024614) PubChem (169132513) PubChem (170117245) PubChem (172400028) | |||
| 5 | M, N, O (A, B, C) | water | water | 18.0 | 8 | Chemie (HOH) |
Sequence modifications
A, B: 67 - 340 (UniProt: P57789)
| PDB | External Database | Details |
|---|---|---|
| Met 66 | - | initiating methionine |
| Ala 341 | - | expression tag |
| Glu 342 | - | expression tag |
| Asn 343 | - | expression tag |
| Leu 344 | - | expression tag |
| Tyr 345 | - | expression tag |
| Phe 346 | - | expression tag |
| Gln 347 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 89416.5 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 2496.2 | |
| All* | Total formula weight | 91912.8 |
