8QZ4
Crystal structure of human two pore domain potassium ion channel TREK-2 (K2P10.1) in complex with an activatory nanobody (Nb76)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Potassium channel subfamily K member 10 | polymer | 282 | 31060.1 | 2 | UniProt (P57789) Pfam (PF00520) Pfam (PF07885) | Homo sapiens (human) | Outward rectifying potassium channel protein TREK-2,TREK-2 K(+) channel subunit |
| 2 | C, D (C, D) | Nanobody 76 | polymer | 123 | 13648.2 | 2 | Lama glama | ||
| 3 | E, F, J, K (A, B) | BARIUM ION | non-polymer | 137.3 | 4 | Chemie (BA) | |||
| 4 | G, H, I, L (A, B) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 4 | Chemie (Y01) | |||
| 5 | M, N, O (A, B, C) | water | water | 18.0 | 8 | Chemie (HOH) |
Sequence modifications
A, B: 67 - 340 (UniProt: P57789)
| PDB | External Database | Details |
|---|---|---|
| Met 66 | - | initiating methionine |
| Ala 341 | - | expression tag |
| Glu 342 | - | expression tag |
| Asn 343 | - | expression tag |
| Leu 344 | - | expression tag |
| Tyr 345 | - | expression tag |
| Phe 346 | - | expression tag |
| Gln 347 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 89416.5 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 2496.2 | |
| All* | Total formula weight | 91912.8 |
