8QYQ
Beta-cardiac myosin S1 fragment in the pre-powerstroke state complexed to Mavacamten
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Myosin-7 | polymer | 807 | 92333.8 | 2 | UniProt (Q9BE39) Pfam (PF02736) Pfam (PF00063) | Bos taurus (cattle) | |
| 2 | C (C) | Myosin light chain 3 | polymer | 199 | 21968.0 | 1 | UniProt (P85100) | Bos taurus (cattle) | Myosin light chain 1,slow-twitch muscle B/ventricular isoform,MLC1SB |
| 3 | D (D) | Myosin light chain 3 | polymer | 199 | 21966.1 | 1 | UniProt (P85100) | Bos taurus (cattle) | |
| 4 | E, L (A, B) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 2 | Chemie (ADP) | |||
| 5 | F, M (A, B) | BERYLLIUM TRIFLUORIDE ION | non-polymer | 66.0 | 2 | Chemie (BEF) | |||
| 6 | G, Q (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 7 | H, N (A, B) | Mavacamten | non-polymer | 273.3 | 2 | Chemie (XB2) | |||
| 8 | I, J, K, O, P (A, B) | FORMIC ACID | non-polymer | 46.0 | 5 | Chemie (FMT) | |||
| 9 | R (C) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 10 | S, T, U, V (A, B, C, D) | water | water | 18.0 | 485 | Chemie (HOH) |
Sequence modifications
D: 1 - 199 (UniProt: P85100)
| PDB | External Database | Details |
|---|---|---|
| Val 151 | Thr 151 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 228601.7 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 1903.9 | |
| All* | Total formula weight | 230505.6 |
