8QYO

Human proteasome 20S core particle

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, O (A, O)	Proteasome subunit alpha type-2	polymer	234	25927.5	2	UniProt (P25787) Pfam (PF10584) Pfam (PF00227)	Homo sapiens (human)	Macropain subunit C3,Multicatalytic endopeptidase complex subunit C3,Proteasome component C3
2	B, P (B, P)	Proteasome subunit alpha type-4	polymer	261	29525.8	2	UniProt (P25789) Pfam (PF10584) Pfam (PF00227)	Homo sapiens (human)	Macropain subunit C9,Multicatalytic endopeptidase complex subunit C9,Proteasome component C9,Proteasome subunit L
3	C, Q (C, Q)	Proteasome subunit alpha type-7	polymer	248	27929.9	2	UniProt (O14818) Pfam (PF10584) Pfam (PF00227)	Homo sapiens (human)	Proteasome subunit RC6-1,Proteasome subunit XAPC7
4	D, R (D, R)	Proteasome subunit alpha type-5	polymer	241	26436.0	2	UniProt (P28066) Pfam (PF10584) Pfam (PF00227)	Homo sapiens (human)	Macropain zeta chain,Multicatalytic endopeptidase complex zeta chain,Proteasome zeta chain
5	E, S (E, S)	Proteasome subunit alpha type-1	polymer	263	29595.6	2	UniProt (P25786) Pfam (PF00227) Pfam (PF10584)	Homo sapiens (human)	30 kDa prosomal protein,PROS-30,Macropain subunit C2,Multicatalytic endopeptidase complex subunit C2,Proteasome component C2,Proteasome nu chain
6	F, T (F, T)	Proteasome subunit alpha type-3	polymer	255	28469.3	2	UniProt (P25788) Pfam (PF10584) Pfam (PF00227)	Homo sapiens (human)	Macropain subunit C8,Multicatalytic endopeptidase complex subunit C8,Proteasome component C8
7	G, U (G, U)	Proteasome subunit alpha type-6	polymer	246	27432.5	2	UniProt (P60900) Pfam (PF10584) Pfam (PF00227)	Homo sapiens (human)	27 kDa prosomal protein,p27K,Macropain iota chain,Multicatalytic endopeptidase complex iota chain,Proteasome iota chain
8	H, V (H, V)	Proteasome subunit beta type-7	polymer	277	30000.4	2	UniProt (Q99436) Pfam (PF00227) Pfam (PF12465)	Homo sapiens (human)	Macropain chain Z,Multicatalytic endopeptidase complex chain Z,Proteasome subunit Z
9	I, W (I, W)	Proteasome subunit beta type-3	polymer	205	22972.9	2	UniProt (P49720) Pfam (PF00227)	Homo sapiens (human)	Proteasome chain 13,Proteasome component C10-II,Proteasome theta chain
10	J, X (J, X)	Proteasome subunit beta type-2	polymer	201	22864.3	2	UniProt (P49721) Pfam (PF00227)	Homo sapiens (human)	Macropain subunit C7-I,Multicatalytic endopeptidase complex subunit C7-I,Proteasome component C7-I
11	K, Y (K, Y)	Proteasome subunit beta type-5	polymer	263	28510.2	2	UniProt (P28074) Pfam (PF00227)	Homo sapiens (human)	Macropain epsilon chain,Multicatalytic endopeptidase complex epsilon chain,Proteasome chain 6,Proteasome epsilon chain,Proteasome subunit MB1,Proteasome subunit X
12	L, Z (L, Z)	Proteasome subunit beta type-1	polymer	241	26522.4	2	UniProt (P20618) Pfam (PF00227)	Homo sapiens (human)	Macropain subunit C5,Multicatalytic endopeptidase complex subunit C5,Proteasome component C5,Proteasome gamma chain
13	AA, M (M, a)	Proteasome subunit beta type-4	polymer	264	29219.1	2	UniProt (P28070) Pfam (PF00227)	Homo sapiens (human)	26 kDa prosomal protein,HsBPROS26,PROS-26,Macropain beta chain,Multicatalytic endopeptidase complex beta chain,Proteasome beta chain,Proteasome chain 3,HsN3
14	BA, N (N, b)	Proteasome subunit beta type-6	polymer	239	25335.6	2	UniProt (P28072) Pfam (PF00227)	Homo sapiens (human)

Sequence modifications

M, a: 1 - 264 (UniProt: P28070)

PDB	External Database	Details
Thr 234	Ile 234	variant

N, b: 1 - 239 (UniProt: P28072)

PDB	External Database	Details
Gly 145	Val 145	variant

Contents of the asymmetric unit

Polymers	Number of chains	28
	Total formula weight	761483.0
All*	Total formula weight	761483.0

*Water molecules are not included.