8QXO

Cryo-EM structure of tetrameric human SAMHD1 State V - Depleted relaxed

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1	polymer	626	72305.4	4	UniProt (Q9Y3Z3) Pfam (PF07647) Pfam (PF01966)	Homo sapiens (human)
2	E, I, O, P (A, B, D)	GUANOSINE-5'-TRIPHOSPHATE	non-polymer		523.2	4	Chemie (GTP)
3	F, J, M, Q (A, B, C, D)	FE (III) ION	non-polymer		55.8	4	Chemie (FE)
4	G, N (A, C)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
5	H, L (B)	2'-DEOXYADENOSINE 5'-TRIPHOSPHATE	non-polymer		491.2	2	Chemie (DTP)
6	K, R (B, D)	2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE	non-polymer		467.2	2	Chemie (DCP)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	289221.7
Non-Polymers*	Number of molecules	14
	Total formula weight	4281.4
All*	Total formula weight	293503.0

*Water molecules are not included.