8QXJ
Cryo-EM structure of tetrameric human SAMHD1 with dApNHpp
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | polymer | 626 | 72305.4 | 4 | UniProt (Q9Y3Z3) Pfam (PF07647) Pfam (PF01966) | Homo sapiens (human) | |
| 2 | BA, E, K, M, R... (D, A, B, C) | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine | non-polymer | 490.2 | 8 | Chemie (DZ4) | |||
| 3 | CA, F, N, U (D, A, B, C) | FE (III) ION | non-polymer | 55.8 | 4 | Chemie (FE) | |||
| 4 | DA, EA, FA, G, H... (D, A, B, C) | MAGNESIUM ION | non-polymer | 24.3 | 12 | Chemie (MG) | |||
| 5 | AA, J, L, Y (D, A, B, C) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 4 | Chemie (GTP) | |||
| 6 | GA, HA, IA, JA (A, B, C, D) | water | water | 18.0 | 214 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 289221.7 | |
| Non-Polymers* | Number of molecules | 28 |
| Total formula weight | 6529.3 | |
| All* | Total formula weight | 295751.0 |
